Evidence map›Paper›PMID 17185799›Full record

ArticleEndocrine2006

Topical ER36009, a RARgamma-selective retinoid, decreases abdominal white adipose tissue and elicits changes in expression of genes related to adiposity and thermogenesis.

Tomohiro Sakuta, Taro Uchiyama, Toshiji Kanayama

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tomohiro SakutaShiseido Pharmaceutical Research Center, 2-12-1 Kanazawa-ku Fukuura, Yokohama, Japan 236-8643. tomohiro.sakuta@to.shiseido.co.jp
Taro Uchiyama
Toshiji Kanayama
Shiseido Group (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic topical treatment of rats with a new RARgamma-selective retinoid, ER36009, resulted in a significant reduction of epididymal white adipose tissue and a significant increase of interscapular brown adipose tissue without affecting food intake. ER36009 markedly decreased PPARgamma, 11beta-HSD1, and Bcl-2 mRNA levels, and increased Bax mRNA in white adipose tissue, while it upregulated UCP1 and UCP3 mRNAs in brown adipose tissue and UCP3 mRNA in gastrocnemial muscle. These results suggest that ER36009 has multiple effects on adipose tissue biology and the energy balance. Topically applied ER36009 may have potential for the treatment of obesity.

Indexed as

11-beta-Hydroxysteroid DehydrogenasesAdipose Tissue, BrownAdipose Tissue, WhiteAdiposityAnimalsbcl-2-Associated X ProteinBlotting, NorthernBody WeightEatingIon ChannelsMaleMitochondrial ProteinsPPAR gammaProto-Oncogene Proteins c-bcl-2QuinoxalinesRats11-beta-Hydroxysteroid Dehydrogenases4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acidBax protein, ratbcl-2-Associated X ProteinIon ChannelsMitochondrial ProteinsPPAR gammaProto-Oncogene Proteins c-bcl-2QuinoxalinesRNA, MessengerThiazolesUcp1 protein, ratUcp3 protein, ratUncoupling Protein 1Uncoupling Protein 3

Identifiers

PMID17185799
OpenAlexW2073357524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.