Evidence map›Paper›PMID 17185647›Full record

ArticleAmerican journal of respiratory and critical care medicine2007

Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.

Tanyalak Parimon, Jason W Chien, Chris L Bryson, Mary B McDonell, Edmunds M Udris, David H Au

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00013130 (Ambulatory Care Quality Improvement), which is not on this map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00013130 phase2completednot on this map

Ambulatory Care Quality Improvement (ACQUIP)

TypeinterventionalSponsorUS Department of Veterans AffairsEnrolled62,487ConditionsHealth Status Measures, Outcomes, Continuous Quality ImprovementArmsProvision of health status information to patients provider
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 203 citations in OpenAlex.

  1. Chronic Obstructive Pulmonary Disease and Lung Cancer: A Meta-Analysis of Risk Association.International journal of chronic obstructive pulmonary disease · 2025
    Pooled it
  2. Methods to assess COPD medications adherence in healthcare databases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  3. Pooled it
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  6. Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD.International journal of chronic obstructive pulmonary disease · 2016
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tanyalak ParimonDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jason W Chien
Chris L Bryson
Mary B McDonell
Edmunds M Udris
David H Au
University of Washington · USHealth Services Research & Development · US

Funding

Genetic epidemiology of TLR4 alleles and bacteremiaK23HL069860 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHIEN, JASON W · 2002 to 2006
$776k
NHLBI NIH HHS K23HL69860
6 · The paper itself

Abstract

RATIONALE AND

objectivesLung cancer is a frequent cause of death among patients with chronic obstructive pulmonary disease (COPD). We examined whether the use of inhaled corticosteroids among patients with COPD was associated with a decreased risk of lung cancer.

methodsWe performed a cohort study of United States veterans enrolled in primary care clinics between December 1996 and May 2001. Participants had received treatment for, had an International Classification of Disease, 9th edition, diagnosis of, or a self-reported diagnosis of COPD. Patients with a history of lung cancer were excluded. To be exposed, patients must have been at least 80% adherent to inhaled corticosteroids. We used Cox regression models to estimate the risk of cancer and adjust for potential confounding factors.

findingsWe identified 10,474 patients with a median follow-up of 3.8 years. In comparison to nonusers of inhaled corticosteroids, adjusting for age, smoking status, smoking intensity, previous history of non-lung cancer malignancy, coexisting illnesses, and bronchodilator use, there was a dose-dependent decreased risk of lung cancer associated with inhaled corticosteroids (ICS dose < 1,200 mug/d: adjusted HR, 1.3; 95% confidence interval, 0.67-1.90; ICS dose >or= 1,200 microg/d: adjusted HR, 0.39; 95% confidence interval, 0.16-0.96). Changes in cohort definitions had minimal effects on the estimated risk. Analyses examining confounding by indication suggest biases in the opposite direction of the described effects.

interpretationResults suggest that inhaled corticosteroids may have a potential role in lung cancer prevention among patients with COPD. These initial findings require confirmation in separate and larger cohorts.

Indexed as

Administration, InhalationAgedCohort StudiesDose-Response Relationship, DrugFemaleGlucocorticoidsHumansLung NeoplasmsMaleMiddle AgedPatient CompliancePulmonary Disease, Chronic ObstructiveRisk AssessmentUnited StatesGlucocorticoids

Identifiers

PMID17185647
PMCPMC1899285
OpenAlexW1979692862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.