Evidence map›Paper›PMID 17185433›Full record

ReviewArchives of disease in childhood. Fetal and neonatal edition2007

Antenatal risk factors, cytokines and the development of atopic disease in early childhood.

E K Chung, R L Miller, M T Wilson, S J McGeady, J F Culhane

Open access · bronzeAbstract readReview
In one paragraph

Review in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  13. Prenatal maternal diet affects asthma risk in offspring.The Journal of clinical investigation · 2008
    Article
  14. Halting the allergic march.The World Allergy Organization journal · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

E K ChungThe Division of General Pediatrics, Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania, USA. echung@nemours.org
R L Miller
M T Wilson
S J McGeady
J F Culhane
Chestnut Hill College · USColumbia University · USCommunity Health Systems - Dupont Hospital · USDrexel University · USHarvard College Observatory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic diseases are complex entities influenced by an array of risk factors, including genetic predisposition, environmental allergens, antenatal exposures, infections and psychosocial factors. One proposed mechanism by which these risk factors contribute to the development of atopic disease is through changes in the production of T helper cell type 1 (Th1) and T helper cell type 2 (Th2) cytokines. The objectives of this review are to discuss antenatal exposures that are associated with paediatric atopic diseases, to discuss the influence of the intrauterine environment on neonatal immune responses, to provide an overview of the Th1 and Th2 pathways and how they relate to atopic disease, and to summarise our current understanding of the association between cytokine responses in cord blood and the development of atopic disease in early childhood.

Indexed as

Child, PreschoolCytokinesEpitopesFemaleFetal BloodHumansHypersensitivityModels, ImmunologicalPregnancyPrenatal Exposure Delayed EffectsRisk FactorsTh1 CellsTh2 CellsCytokinesEpitopes

Identifiers

PMID17185433
PMCPMC2675311
OpenAlexW2122785158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.