Evidence map›Paper›PMID 17185356›Full record

SynthesisGut2007

A meta-analysis on the influence of inflammatory bowel disease on pregnancy.

J Cornish, E Tan, J Teare, T G Teoh, R Rai, S K Clark, P P Tekkis

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03091309 (Counseling to Optimize Medication Adherence in Expectant Mothers With Inflammatory Bowel Disease), which is not on this map. Cited by 132 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 11 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03091309 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Counseling to Optimize Medication Adherence in Expectant Mothers With Inflammatory Bowel Disease (COACH-IBD)

TypeinterventionalSponsorMount Sinai Hospital, CanadaRan2017 to 2020Enrolled220ConditionsInflammatory Bowel Diseases, Medication Adherence, Crohn Disease, Ulcerative ColitisArmsInteractive educational video, Initial in-person counseling with an IBD nurse, Motivational interviewing, Telemedicine-based follow-up, Monthly follow-up questionnaires
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 11 syntheses or guidelines pooled it, 459 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  11. Indian Society of Gastroenterology consensus on ulcerative colitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2012
    Guideline
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

J CornishDepartment of Biosurgery and Surgical Technology, St Mary's Hospital, Imperial College, 10th Floor QEQM Wing, Praed Street, London W2 1NY, UK.
E Tan
J Teare
T G Teoh
R Rai
S K Clark
P P Tekkis
St Mary's Hospital · GBImperial College London · GBSt Mark's Hospital · GBSt Mary's Hospital · GBSt. Mary's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory bowel disease (IBD) has a typical onset during the peak reproductive years. Evidence of the risk of adverse pregnancy outcomes in IBD is important for the management of pregnancy to assist in its management.

aimTo provide a clear assessment of risk of adverse outcomes during pregnancy in women with IBD.

designThe Medline literature was searched to identify studies reporting outcomes of pregnancy in patients with IBD. Random-effect meta-analysis was used to compare outcomes between women with IBD and normal controls. PATIENTS AND

settingA total of 3907 patients with IBD (Crohn's disease 1952 (63%), ulcerative colitis 1113 (36%)) and 320 531 controls were reported in 12 studies that satisfied the inclusion criteria.

resultsFor women with IBD, there was a 1.87-fold increase in incidence of prematurity (<37 weeks gestation; 95% CI 1.52 to 2.31; p<0.001) compared with controls. The incidence of low birth weight (<2500 g) was over twice that of normal controls (95% CI 1.38 to 3.19; p<0.001). Women with IBD were 1.5 times more likely to undergo caesarean section (95% CI 1.26 to 1.79; p<0.001), and the risk of congenital abnormalities was found to be 2.37-fold increased (95% CI 1.47 to 3.82; p<0.001).

conclusionThe study has shown a higher incidence of adverse pregnancy outcomes in patients with IBD. Further studies are required to clarify which women are at higher risk, as this was not determined in the present study. This has an effect on the management of patients with IBD during pregnancy, who should be treated as a potentially high-risk group.

Indexed as

Pregnancy ComplicationsPregnancy OutcomeBirth WeightCongenital AbnormalitiesDelivery, ObstetricFemaleHumansInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeInflammatory Bowel DiseasesPregnancyPrenatal Exposure Delayed EffectsPublication BiasSensitivity and Specificity

Identifiers

PMID17185356
PMCPMC1954859
OpenAlexW2100626976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.