ArticleGut2007
Norepinephrine increases the pathogenic potential of Campylobacter jejuni.
Article in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?Frontiers in cellular and infection microbiology · 2021Pooled it
- Review
- Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs.PLoS biology · 2026Article
- EnterohemorrhagicmSystems · 2026Article
- The prairie vole gut-brain-microbiota-axis: a narrative review.Gut microbiome (Cambridge, England) · 2026Review
- External factors influence intrinsic differences in Stx2e production by Porcine Shiga Toxin-producing Escherichia coli strains.PLoS pathogens · 2025Article
- Whole-body mass spectrometry imaging reveals the systemic metabolic disorder and catecholamines biosynthesis alteration on heart-gut axis in heart failure rat.Journal of advanced research · 2025Article
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Spatial sensing as a strategy for public goods regulation by gut microbes.The ISME journal · 2025Article
- Effects of the stress hormone norepinephrine on the probiotic properties ofFrontiers in microbiology · 2025Article
- The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review.Nutrients · 2024Review
- Ex vivo and miniaturized in vitro3 Biotech · 2024Review
- Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis.Critical care (London, England) · 2024Review
- Cold stress initiates catecholaminergic and serotonergic responses in the chicken gut that are associated with functional shifts in the microbiome.Poultry science · 2024Article
- Exploring the management and treatment of IBD from the perspective of psychological comorbidities.Therapeutic advances in gastroenterology · 2024Review
- Prediction of edapho-climatic parameters in the incidence of Campylobacter spp. in northwestern Mexico.PLOS global public health · 2024Article
- The crosstalk of the pathophysiologic models in fibromyalgia.Clinical rheumatology · 2023Review
- Effects of Catecholamine Stress Hormones Norepinephrine and Epinephrine on Growth, Antimicrobial Susceptibility, Biofilm Formation, and Gene Expressions of EnterotoxigenicInternational journal of molecular sciences · 2023Article
- Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance.Journal of clinical medicine · 2023Review
- New hope for Parkinson's disease treatment: Targeting gut microbiota.CNS neuroscience & therapeutics · 2022Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCampylobacter jejuni can cause a spectrum of diseases in humans, ranging from enteritis and diarrhoea to severe inflammation, profuse bloody diarrhoea and chronic relapsing infection. Norepinephrine (NE) levels in the intestine increase under conditions of stress and trauma, and are thought to result in spill over of NE into the intestinal lumen. NE is known to stimulate the growth of a range of bacterial species, and to increase the pathogenicity of Escherichia coli.
aimTo determine the effects of NE on the pathogenic potential of C jejuni in a model system.
methodsC jejuni was grown in iron-replete and iron-limited media in the presence and absence of 100 microM NE. Several virulence-associated characteristics, including motility and cell invasion, were measured.
resultsWhen C jejuni was grown in iron-limited media in the presence of NE, growth rate, motility and invasion of cultured epithelial cells were increased compared with cultures grown in the absence of NE. Bacteria exposed to NE during growth also caused greater subsequent disruption of cultured epithelial cell monolayers, inducing widespread breakdown of tight junctions.
conclusionExposure to NE causes an increase in the virulence-associated properties of Campylobacter. Stress and concomitant infection could therefore be contributory factors to the variable presentation of this disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.