ArticleGenome biology2006
Multiple independent evolutionary solutions to core histone gene regulation.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
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- Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer.International journal of molecular sciences · 2024Review
- Gene loss and cis-regulatory novelty shaped core histone gene evolution in the apiculate yeast Hanseniaspora uvarum.Genetics · 2024Article
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- Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination.bioRxiv : the preprint server for biology · 2023Article
- Construction and analysis of protein-protein interaction networks based on nuclear proteomics data of the desiccation-tolerantCommunicative & integrative biology · 2023Article
- Transcription coordinates histone amounts and genome content.Nature communications · 2021Article
- Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle.The Journal of cell biology · 2019Review
- Bidirectional histone-gene promoters inFungal biology and biotechnology · 2019Article
- Proteomic View of the Crosstalk betweenFrontiers in microbiology · 2017Article
- Article
- Uncovering the forces between nucleosomes using DNA origami.Science advances · 2016Article
- HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants.Database : the journal of biological databases and curation · 2016Article
- The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences.Genetics & epigenetics · 2016Review
- Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.Current opinion in structural biology · 2015Review
- Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita.Frontiers in physiology · 2014Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- Spt10 and Swi4 control the timing of histone H2A/H2B gene activation in budding yeast.Molecular and cellular biology · 2011Article
- The Histone Database: an integrated resource for histones and histone fold-containing proteins.Database : the journal of biological databases and curation · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCore histone genes are periodically expressed along the cell cycle and peak during S phase. Core histone gene expression is deeply evolutionarily conserved from the yeast Saccharomyces cerevisiae to human.
resultsWe evaluated the evolutionary dynamics of the specific regulatory mechanisms that give rise to the conserved histone regulatory phenotype. In contrast to the conservation of core histone gene expression patterns, the core histone regulatory machinery is highly divergent between species. There has been substantial evolutionary turnover of cis-regulatory sequence motifs along with the transcription factors that bind them. The regulatory mechanisms employed by members of the four core histone families are more similar within species than within gene families. The presence of species-specific histone regulatory mechanisms is opposite to what is seen at the protein sequence level. Core histone proteins are more similar within families, irrespective of their species of origin, than between families, which is consistent with the shared common ancestry of the members of individual histone families. Structure and sequence comparisons between histone families reveal that H2A and H2B form one related group whereas H3 and H4 form a distinct group, which is consistent with the nucleosome assembly dynamics.
conclusionThe dissonance between the evolutionary conservation of the core histone gene regulatory phenotypes and the divergence of their regulatory mechanisms indicates a highly dynamic mode of regulatory evolution. This distinct mode of regulatory evolution is probably facilitated by a solution space for promoter sequences, in terms of functionally viable cis-regulatory sites, that is substantially greater than that of protein sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.