ArticleBMC genomics2006
The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins (Aptenodytes patagonicus).Immunogenetics · 2026Article
- A new chromosome-scale duck genome shows a major histocompatibility complex with several expanded multigene families.BMC biology · 2024Article
- Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data.Frontiers in genetics · 2022Article
- Polymorphism and varying selection within the MHC class I of four Anas species.Immunogenetics · 2021Article
- Long-Read Genome Assemblies Reveal Extraordinary Variation in the Number and Structure of MHC Loci in Birds.Genome biology and evolution · 2021Article
- The quail genome: insights into social behaviour, seasonal biology and infectious disease response.BMC biology · 2020Article
- Polymorphism of MHC class IIB in an acheilognathid species, Rhodeus sinensis shaped by historical selection and recombination.BMC genetics · 2019Article
- Review
- Article
- Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail.Scientific reports · 2018Article
- Structure and polymorphisms of the major histocompatibility complex in the Oriental stork, Ciconia boyciana.Scientific reports · 2017Article
- New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.BMC evolutionary biology · 2016Article
- Genetic variation of the major histocompatibility complex (MHC class II B gene) in the threatened Hume's pheasant, Syrmaticus humiae.PloS one · 2015Article
- Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.PloS one · 2014Article
- Structure and polymorphism of the major histocompatibility complex class II region in the Japanese Crested Ibis, Nipponia nippon.PloS one · 2014Article
- Characteristics of MHC class I genes in house sparrows Passer domesticus as revealed by long cDNA transcripts and amplicon sequencing.Journal of molecular evolution · 2013Article
- Greater prairie chickens have a compact MHC-B with a single class IA locus.Immunogenetics · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- Sequencing of the core MHC region of black grouse (Tetrao tetrix) and comparative genomics of the galliform MHC.BMC genomics · 2012Article
- Isolation of a 97-kb minimal essential MHC B locus from a new reverse-4D BAC library of the golden pheasant.PloS one · 2012Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe quail and chicken major histocompatibility complex (Mhc) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of duplicated class I, class IIB, natural killer (NK)-receptor-like, lectin-like and BG genes. Therefore, the elucidation of genetic factors that contribute to the greater Mhc diversity in the quail would help to establish it as a model experimental animal in the investigation of avian Mhc associated diseases. AIMS AND APPROACHES: The main aim here was to characterize the genetic and genomic features of the transcribed major quail MhcIIB (CojaIIB) region that is located between the Tapasin and BRD2 genes, and to compare our findings to the available information for the chicken MhcIIB (BLB). We used four approaches in the study of the quail MhcIIB region, (1) haplotype analyses with polymorphic loci, (2) cloning and sequencing of the RT-PCR CojaIIB products from individuals with different haplotypes, (3) genomic sequencing of the CojaIIB region from the individuals with the different haplotypes, and (4) phylogenetic and duplication analysis to explain the variability of the region between the quail and the chicken.
resultsOur results show that the Tapasin-BRD2 segment of the quail Mhc is highly variable in length and in gene transcription intensity and content. Haplotypic sequences were found to vary in length between 4 to 11 kb. Tapasin-BRD2 segments contain one or two major transcribed CojaIIBs that were probably generated by segmental duplications involving c-type lectin-like genes and NK receptor-like genes, gene fusions between two CojaIIBs and transpositions between the major and minor CojaIIB segments. The relative evolutionary speed for generating the MhcIIBs genomic structures from the ancestral BLB2 was estimated to be two times faster in the quail than in the chicken after their separation from a common ancestor. Four types of genomic rearrangement elements (GRE), composed of simple tandem repeats (STR), were identified in the MhcIIB genomic segment located between the Tapasin-BRD2 genes. The GREs have many more STR numbers in the quail than in the chicken that displays strong linkage disequilibrium.
conclusionThis study suggests that the Mhc classIIB region has a flexible genomic structure generated by rearrangement elements and rapid SNP accumulation probably as a consequence of the quail adapting to environmental conditions and pathogens during its migratory history after its divergence from the chicken.
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