ArticlePloS one2006
Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo.
Article in PloS one, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.Cell death & disease · 2026Article
- Kinase Inhibitors in Genetic Diseases.International journal of molecular sciences · 2023Review
- Article
- WNT Signaling in Disease.Cells · 2019Review
- Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process.Development (Cambridge, England) · 2019Article
- Article
- An embryonic system to assess direct and indirect Wnt transcriptional targets.Scientific reports · 2017Article
- Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.Scientific reports · 2017Article
- Scaling of cytoskeletal organization with cell size inMolecular biology of the cell · 2017Article
- Review
- Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila.Biology open · 2016Article
- Article
- Primary cilia and kidney injury: current research status and future perspectives.American journal of physiology. Renal physiology · 2013Review
- Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat.Development (Cambridge, England) · 2013Article
- PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.The EMBO journal · 2011Article
- dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis.Development (Cambridge, England) · 2011Article
- Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.PloS one · 2011Article
- Article
- Line up and listen: Planar cell polarity regulation in the mammalian inner ear.Seminars in cell & developmental biology · 2009Review
- Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To generate specialized structures, cells must obtain positional and directional information. In multi-cellular organisms, cells use the non-canonical Wnt or planar cell polarity (PCP) signaling pathway to establish directionality within a cell. In vertebrates, several Wnt molecules have been proposed as permissible polarity signals, but none has been shown to provide a directional cue. While PCP signaling components are conserved from human to fly, no PCP ligands have been reported in Drosophila. Here we report that in the epidermis of the Drosophila embryo two signaling molecules, Hedgehog (Hh) and Wingless (Wg or Wnt1), provide directional cues that induce the proper orientation of Actin-rich structures in the larval cuticle. We further find that proper polarity in the late embryo also involves the asymmetric distribution and phosphorylation of Armadillo (Arm or beta-catenin) at the membrane and that interference with this Arm phosphorylation leads to polarity defects. Our results suggest new roles for Hh and Wg as instructive polarizing cues that help establish directionality within a cell sheet, and a new polarity-signaling role for the membrane fraction of the oncoprotein Arm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.