ArticlePloS one2006
Running speed in mammals increases with muscle n-6 polyunsaturated fatty acid content.
Article in PloS one, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- The Fatty Acid Content, Health Lipid Indices, and Instrumental, Histological, and Sensory Quality of Hare Meat (Foods (Basel, Switzerland) · 2025Article
- Summer fades, deer change: Photoperiodic control of cellular seasonal acclimatization of skeletal muscle.iScience · 2024Article
- Patterns of fatty acid usage in two nocturnal insectivores: the Mediterranean house gecko (Hemidactylus turcicus) and the Etruscan pygmy shrew (Suncus etruscus).The Journal of experimental biology · 2023Article
- Effects of Sex and Hunting Season on Carcass and Meat Quality Characteristics of the Brown Hare (Foods (Basel, Switzerland) · 2023Article
- Hepatic lipid signatures of little brown bats (Myotis lucifugus) and big brown bats (Eptesicus fuscus) at early stages of white-nose syndrome.Scientific reports · 2021Article
- The effects of dietary linoleic acid and hydrophilic antioxidants on basal, peak, and sustained metabolism in flight-trained European starlings.Ecology and evolution · 2020Article
- Fatty acid profiles of the European migratory common noctule bat (Nyctalus noctula).Die Naturwissenschaften · 2019Article
- Dietary polyunsaturated fatty acids influence flight muscle oxidative capacity but not endurance flight performance in a migratory songbird.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?Frontiers in physiology · 2019Review
- Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study.GeroScience · 2017Article
- Activity of Selected Antioxidant Enzymes, Selenium Content and Fatty Acid Composition in the Liver of the Brown Hare (Lepus europaeus L.) in Relation to the Season of the Year.Biological trace element research · 2015Article
- The European Hare (Lepus europaeus): A Picky Herbivore Searching for Plant Parts Rich in Fat.PloS one · 2015Article
- Phospholipid composition and longevity: lessons from Ames dwarf mice.Age (Dordrecht, Netherlands) · 2013Article
- Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet.International journal of molecular sciences · 2010Article
- Plasma polyunsaturated fatty acids and age-related physical performance decline.Rejuvenation research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids (PUFAs) are important dietary components that mammals cannot synthesize de novo. Beneficial effects of PUFAs, in particular of the n-3 class, for certain aspects of animal and human health (e.g., cardiovascular function) are well known. Several observations suggest, however, that PUFAs may also affect the performance of skeletal muscles in vertebrates. For instance, it has been shown that experimentally n-6 PUFA-enriched diets increase the maximum swimming speed in salmon. Also, we recently found that the proportion of PUFAs in the muscle phospholipids of an extremely fast runner, the brown hare (Lepus europaeus), are very high compared to other mammals. Therefore, we predicted that locomotor performance, namely running speed, should be associated with differences in muscle fatty acid profiles. To test this hypothesis, we determined phospholipid fatty acid profiles in skeletal muscles of 36 mammalian species ranging from shrews to elephants. We found that there is indeed a general positive, surprisingly strong relation between the n-6 PUFAs content in muscle phospholipids and maximum running speed of mammals. This finding suggests that muscle fatty acid composition directly affects a highly fitness-relevant trait, which may be decisive for the ability of animals to escape from predators or catch prey.
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