ArticlePloS one2006
Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells.
Article in PloS one, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Unlocking the HOX: Homeobox Genes as Regulators of Hematopoietic Development.International journal of molecular sciences · 2026Review
- HOXA9 orchestrates EMT and metastasis in oral cancer via transcriptional activation of vimentin and β-catenin signaling.Cell death & disease · 2026Article
- Dysregulation of HOXA genes in acute myeloid leukemia and targeted therapy.NPJ precision oncology · 2025Review
- Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis.Clinical and experimental medicine · 2024Article
- HOXA9 transcription factor is a double-edged sword: from development to cancer progression.Cancer metastasis reviews · 2024Review
- HOXA9 Regulome and Pharmacological Interventions in Leukemia.Advances in experimental medicine and biology · 2024Review
- Hypoxic metabolism in human hematopoietic stem cells.Cell & bioscience · 2015Article
- Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis.Oncogenesis · 2014Article
- Sox9-related signaling controls zebrafish juvenile ovary-testis transformation.Cell death & disease · 2013Article
- Caudal genes in blood development and leukemia.Annals of the New York Academy of Sciences · 2012Review
- Review
- Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw.PloS one · 2012Article
- Epigenetic regulations in hematopoietic Hox code.Oncogene · 2011Review
- Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis.Haematologica · 2010Article
- Article
- Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin.Oncogene · 2009Article
- Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.Blood · 2009Article
- Article
- Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.Current molecular medicine · 2008Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTranscription factor Cdx4 and transcriptional coregulator menin are essential for Hoxa9 expression and normal hematopoiesis. However, the precise mechanism underlying Hoxa9 regulation is not clear. METHODS AND
findingsHere, we show that the expression level of Hoxa9 is correlated with the location of increased trimethylated histone 3 lysine 4 (H3K4M3). The active and repressive histone modifications co-exist along the Hoxa9 regulatory region. We further demonstrate that both Cdx4 and menin bind to the same regulatory region at the Hoxa9 locus in vivo, and co-activate the reporter gene driven by the Hoxa9 cis-elements that contain Cdx4 binding sites. Ablation of menin abrogates Cdx4 access to the chromatin target and significantly reduces both active and repressive histone H3 modifications in the Hoxa9 locus.
conclusionThese results suggest a functional link among Cdx4, menin and histone modifications in Hoxa9 regulation in hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.