ArticleJournal of epidemiology and community health2007
Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA Study.
Article in Journal of epidemiology and community health, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Intermediate Risk Management. MARK Study
Identificación de la poBlación Española de RIesgo CArdiovascular y reNal
Validity and Effectiveness of a Method for Self-screening of Cardiovascular Risk
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Research inefficiencies in external validation studies of the Framingham Wilson coronary heart disease risk rule: A systematic review.PloS one · 2024Pooled it
- Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis.BMC medicine · 2019Pooled it
- Guideline
- [Spanish Adaptation of the 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice].Revista espanola de salud publica · 2016Guideline
- Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study).The international journal of behavioral nutrition and physical activity · 2021Trial
- Trial
- Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design.BMC neurology · 2013Trial
- Impact of a self-care education programme on patients with type 2 diabetes in primary care in the Basque Country.BMC public health · 2013Trial
- Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease.BMC research notes · 2012Trial
- Improving interMediAte risk management. MARK study.BMC cardiovascular disorders · 2011Trial
- Sex andInternational journal of molecular sciences · 2025Article
- Long-Term Effectiveness of Acetylsalicylic Acid in Primary Prevention of Cardiovascular Diseases and Mortality in Patients at High Risk, a Retrospective Cohort Study-The JOANA Study.Journal of clinical medicine · 2025Article
- Cohort Profile: The Girona Heart Registry.International journal of epidemiology · 2025Article
- First manifestation of cardiovascular disease according to age and sex in a Mediterranean country.Frontiers in cardiovascular medicine · 2024Article
- Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study.International journal of molecular sciences · 2023Article
- Cardiometabolic profile of 15057 elderly Spanish workers: association of sociodemographic variables and tobacco consumption.BMC geriatrics · 2022Article
- Determination of cardiovascular risk in 192,711 underweight and normal weight workers.Turkish journal of medical sciences · 2022Article
- Usefulness of Cardiac Computed Tomography in Coronary Risk Prediction: A Five-Year Follow-Up of the SPICA Study (Secure Prevention with Imaging of the Coronary Arteries).Journal of clinical medicine · 2022Article
- Differences in cardiovascular risk levels between cleaning staff and hotel housekeepers.Journal of occupational health · 2022Article
- Cholesterol and Hypertension Treatment Improve Coronary Risk Prediction but Not Time-Dependent Covariates or Competing Risks.Clinical epidemiology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the reliability and accuracy of the Framingham coronary heart disease (CHD) risk function adapted by the Registre Gironí del Cor (REGICOR) investigators in Spain.
methodsA 5-year follow-up study was completed in 5732 participants aged 35-74 years. The adaptation consisted of using in the function the average population risk factor prevalence and the cumulative incidence observed in Spain instead of those from Framingham in a Cox proportional hazards model. Reliability and accuracy in estimating the observed cumulative incidence were tested with the area under the curve comparison and goodness-of-fit test, respectively.
resultsThe Kaplan-Meier CHD cumulative incidence during the follow-up was 4.0% in men and 1.7% in women. The original Framingham function and the REGICOR adapted estimates were 10.4% and 4.8%, and 3.6% and 2.0%, respectively. The REGICOR-adapted function's estimate did not differ from the observed cumulated incidence (goodness of fit in men, p = 0.078, in women, p = 0.256), whereas all the original Framingham function estimates differed significantly (p<0.001). Reliabilities of the original Framingham function and of the best Cox model fit with the study data were similar in men (area under the receiver operator characteristic curve 0.68 and 0.69, respectively, p = 0.273), whereas the best Cox model fitted better in women (0.73 and 0.81, respectively, p<0.001).
conclusionThe Framingham function adapted to local population characteristics accurately and reliably predicted the 5-year CHD risk for patients aged 35-74 years, in contrast with the original function, which consistently overestimated the actual risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.