ArticleGenes & development2006
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 99 citations in OpenAlex.
- Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching.International journal of molecular sciences · 2024Review
- When Dad's Stress Gets under Kid's Skin-Impacts of Stress on Germline Cargo and Embryonic Development.Biomolecules · 2023Review
- Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development.Genes · 2023Review
- Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation.The Journal of biological chemistry · 2021Article
- Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity.Nature communications · 2020Article
- DNA methylation in disease: Immunodeficiency, Centromeric instability, Facial anomalies syndrome.Essays in biochemistry · 2019Review
- The influence of DNA methylation on monoallelic expression.Essays in biochemistry · 2019Review
- Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.Life science alliance · 2019Article
- Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development.Journal of cellular biochemistry · 2018Article
- Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease.BMC genomics · 2018Article
- The expression of DNA methyltransferases3A is specifically downregulated in chorionic villi of early embryo growth arrest cases.Molecular medicine reports · 2017Article
- The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.Human molecular genetics · 2016Article
- Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice.Reproduction (Cambridge, England) · 2016Article
- Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation.Developmental cell · 2016Article
- The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.Nucleic acids research · 2016Article
- DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer.Molecular cancer research : MCR · 2016Article
- Longitudinal study of DNA methylation during the first 5 years of life.Journal of translational medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is a major epigenetic mechanism that has been suggested to control developmental gene regulation during embryogenesis, but its regulatory mechanisms remain unclear. In this report, we show that CpG islands associated with the X-linked homeobox gene cluster Rhox, which is highly expressed in the extraembryonic trophectoderm, are differentially methylated in a stage- and lineage-specific manner during the post-implantation development of mice. Inactivation of both Dnmt3a and Dnmt3b, DNA methyltransferases essential for the initiation of de novo DNA methylation, abolished the establishment of DNA methylation and the silencing of Rhox cluster genes in the embryo proper. The Dnmt3-dependent CpG-island methylation at the Rhox locus extended for a large genomic region ( approximately 1 Mb) containing the Rhox cluster and surrounding genes. Complementation experiments using embryonic stem (ES) cells deficient in the DNA methyltransferases suggested that the CpG-island methylation by Dnmt3a and Dnmt3b was restricted within this large genomic region, and did not affect the neighboring genes outside it, implicating the existence of region-specific boundaries. Our results suggest that DNA methylation plays important roles in both long-range gene silencing and lineage-specific silencing in embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.