ArticleMolecular biology of the cell2007
Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- Immunogens in Balamuthia mandrillaris: a proteomic exploration.Parasitology research · 2024Article
- Characterisation of TbSmee1 suggests endocytosis allows surface-bound cargo to enter the trypanosome flagellar pocket.Journal of cell science · 2023Article
- Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies.International journal of molecular sciences · 2023Review
- ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan ParasiteFrontiers in cellular and infection microbiology · 2021Article
- Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics.Biomolecules · 2019Review
- Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Recombinant protein ofOncotarget · 2017Article
- Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.Journal of medicinal chemistry · 2017Article
- A role for Sar1 and ARF1 GTPases during Golgi biogenesis in the protozoan parasiteMolecular biology of the cell · 2017Article
- The N-myristoylome of Trypanosoma cruzi.Scientific reports · 2016Article
- Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness ParasiteACS infectious diseases · 2016Article
- A MORN Repeat Protein Facilitates Protein Entry into the Flagellar Pocket of Trypanosoma brucei.Eukaryotic cell · 2015Article
- Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.Journal of medicinal chemistry · 2014Article
- Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.The Biochemical journal · 2014Article
- TbFRP, a novel FYVE-domain containing phosphoinositide-binding Ras-like GTPase from trypanosomes.Experimental parasitology · 2013Article
- A new, robust, and nonradioactive approach for exploring N-myristoylation.Journal of lipid research · 2012Article
- A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.Biochimica et biophysica acta · 2012Article
- Article
- ARF family G proteins and their regulators: roles in membrane transport, development and disease.Nature reviews. Molecular cell biology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The ADP ribosylation factor (Arf)1 orthologue in the divergent eukaryote Trypanosoma brucei (Tb) shares characteristics with both Arf1 and Arf6 and has a vital role in intracellular protein trafficking. TbARF1 is Golgi localized in trypanosomes but associates with the plasma membrane when expressed in human cells. Depletion of TbARF1 by RNA interference causes a major decrease in endocytosis, which correlates with Rab5 dissociation from early endosomes. Although the Golgi remains intact, parasites display enlarged flagellar pockets and intracellular flagella. An increase in active GTP-bound TbARF1 in bloodstream parasites is rapidly lethal, correlating with a defect in Golgi-to-lysosome transport. We conclude that the essential Golgi-localizing T. brucei ARF1 has a primary role in the maintenance of both post-Golgi transport and endocytosis and that it is significantly divergent from other characterized ARFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.