ArticleClinical and vaccine immunology : CVI2007
Development of serological assays for Thottapalayam virus, an insectivore-borne Hantavirus.
Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Development of a seroepidemiological tool for bat-borne and shrew-borne hantaviruses and its application using samples from Zambia.PLoS neglected tropical diseases · 2024Article
- 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of a Panel of Cross-Reactive Hantavirus Nucleocapsid Protein-Specific Monoclonal Antibodies.Viruses · 2023Article
- The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances?Viruses · 2021Article
- Hantavirus entry: Perspectives and recent advances.Advances in virus research · 2019Article
- A mini-review of Bunyaviruses recorded in India.The Indian journal of medical research · 2017Review
- Epizootiological study of rodent-borne hepatitis E virus HEV-C1 in small mammals in Hanoi, Vietnam.The Journal of veterinary medical science · 2017Article
- Review
- Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses.Virology · 2012Article
- Emerging Viral Infections in India.Proceedings of the National Academy of Sciences, India. Section B · 2012Article
- Rodent-borne hantaviruses in Cambodia, Lao PDR, and Thailand.EcoHealth · 2011Article
- Short report: Genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal.The American journal of tropical medicine and hygiene · 2011Article
- Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2010Article
- Novel hantavirus in the flat-skulled shrew (Sorex roboratus).Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2010Article
- A global perspective on hantavirus ecology, epidemiology, and disease.Clinical microbiology reviews · 2010Review
- Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura).Journal of virology · 2009Article
- Hantaviruses: an emerging public health threat in India? A review.Journal of biosciences · 2008Review
- Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Hantavirus in northern short-tailed shrew, United States.Emerging infectious diseases · 2007Article
- Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus).Virology journal · 2007Article
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thottapalayam virus (TPMV), a member of the genus Hantavirus in the family Bunyaviridae, was isolated from an insectivore, Suncus murinus (musk shrew), captured in southern India in 1964. While the isolation of TPMV predates the discovery of the prototype Hantaan virus, little is known about its genetics and biology. To date, preliminary evidence suggests that TPMV differs significantly, both antigenically and genetically, from all known rodent-borne hantaviruses. However, since detailed epizootiological studies have not been conducted, it is unclear if TPMV is naturally harbored by an insectivore host or if TPMV represents a "spillover" from its natural rodent reservoir host. Moreover, to what extent TPMV causes infection and/or disease in humans is not known. To address these issues, we first studied the antigenic profile of TPMV using monoclonal antibodies against Hantaan and Seoul viruses and polyclonal immune sera against Puumala virus and TPMV. Armed with this newfound information, we developed an enzyme-linked immunosorbent assay system for the diagnosis of TPMV infections in shrews and humans, using a recombinant TPMV N antigen manipulated to have an E5/G6 epitope to be captured by monoclonal antibody clone E5/G6. Using this assay, we found anti-TPMV antibodies in sera from a patient with high fever of unknown etiology in Thailand and from two shrews captured in Indonesia. Seropositivity was verified by the indirect immunofluorescence antibody test, Western blotting analysis, and focus reduction neutralization test. Collectively, our data indicate that TPMV is harbored by Suncus murinus as its host in nature and is capable of infecting humans.
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