ArticleProceedings of the National Academy of Sciences of the United States of America2007
A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Osteoblast-derived CAR3 synergizing with collagen and bone sialoprotein enhances bone formation.International journal of oral science · 2026Article
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation.FEBS open bio · 2022Article
- Low duty cycle pulse trains for exchange rate insensitive chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2021Article
- Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Reduced expression of carbonic anhydrase III in skeletal muscles could be linked to muscle fatigue: A rat muscle fatigue model.Journal of orthopaedic translation · 2020Article
- Naturally Produced Lovastatin Modifies the Histology and Proteome Profile of Goat Skeletal Muscle.Animals : an open access journal from MDPI · 2019Article
- Transgenic expression of carbonic anhydrase III in cardiac muscle demonstrates a mechanism to tolerate acidosis.American journal of physiology. Cell physiology · 2019Article
- Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Chemical exchange saturation transfer imaging of phosphocreatine in the muscle.Magnetic resonance in medicine · 2019Article
- Article
- Carbonic Anhydrase III Is Expressed in Mouse Skeletal Muscles Independent of Fiber Type-Specific Myofilament Protein Isoforms and Plays a Role in Fatigue Resistance.Frontiers in physiology · 2016Article
- Gender-dimorphic regulation of DJ1 and its interactions with metabolic proteins in streptozotocin-induced diabetic rats.Journal of cellular and molecular medicine · 2015Article
- In vivo (31)P NMR spectroscopy assessment of skeletal muscle bioenergetics after spinal cord contusion in rats.European journal of applied physiology · 2014Article
- Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.PloS one · 2014Article
- Comprehensive phenotyping of group III and IV muscle afferents in mouse.Journal of neurophysiology · 2013Article
- Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Expression and purification of TAT-fused carbonic anhydrase III and its effect on C2C12 cell apoptosis induced by hypoxia/reoxygenation.Archives of medical science : AMS · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Oxidative slow skeletal muscle contains carbonic anhydrase III in high concentration, but its primary function remains unknown. To determine whether its lack handicaps energy metabolism and/or acid elimination, we measured the intracellular pH and energy phosphates by (31)P magnetic resonance spectroscopy in hind limb muscles of wild-type and CA III knockout mice during and after ischemia and intense exercise (electrical stimulation). Thirty minutes of ischemia caused phosphocreatine (PCr) to fall and P(i) to rise while pH and ATP remained constant in both strains of mice. PCr and P(i) kinetics during ischemia and recovery were not significantly different between the two genotypes. From this we conclude that under neutral pH conditions resting muscle anaerobic metabolism, the rate of the creatine kinase reaction, intracellular buffering of protons, and phosphorylation of creatine by mitochondrial oxygen metabolism are not influenced by the lack of CA III. Two minutes of intense stimulation of the mouse gastrocnemius caused PCr, ATP, and pH to fall and ADP and P(i) to rise, and these changes, with the exception of ATP, were all significantly larger in the CA III knockouts. The rate of return of pH and ADP to control values was the same in wild-type and mutant mice, but in the mutants PCr and P(i) recovery were delayed in the first minute after stimulation. Because the tension decrease during fatigue is known to be the same in the two genotypes, we conclude that a lack of CA III impairs mitochondrial ATP synthesis.
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