ReviewPsychopharmacology2007
Risk of adverse behavioral effects with pediatric use of antidepressants.
Review in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD.Psychiatry research · 2013Trial
- Suicidal events in the Treatment for Adolescents With Depression Study (TADS).The Journal of clinical psychiatry · 2009Trial
- Activation adverse events induced by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescents.Journal of child and adolescent psychopharmacology · 2009Trial
- Reactivity of Olanzapine and Tricyclic Antidepressants on the Protective Effects of Trolox on Lipid Peroxidation Evaluated Using Fluorescence Anisotropy, Electron Paramagnetic Resonance Spectrometry, and Thermal Analysis.ACS chemical neuroscience · 2025Article
- A systematic review of selective serotonin reuptake inhibitor (SSRI)-induced activation and manic/hypomanic switch in children and adolescents.Scandinavian journal of child and adolescent psychiatry and psychology · 2025Review
- Psychotropic Medications Promote Time-Dependent Reduction of Suicidal Ideation in Mood Disorder: A Prospective Cohort Study.Journal of Korean medical science · 2024Article
- Multimodal Mental Health Digital Biomarker Analysis From Remote Interviews Using Facial, Vocal, Linguistic, and Cardiovascular Patterns.IEEE journal of biomedical and health informatics · 2024Article
- Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods.Psychiatry research communications · 2023Article
- The Change of Suicidal Ideation Over a 12-Week Naturalistic Treatment of Depression: Comparison Between Young People and Older Adults.Psychiatry investigation · 2023Article
- Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs).Current neuropharmacology · 2022Review
- The Moderating Role of Child Maltreatment in Treatment Efficacy for Adolescent Depression.Journal of abnormal child psychology · 2020Article
- Commentary: Duty to Warn: Antidepressant Black Box Suicidality Warning is Empirically Justified.Frontiers in psychiatry · 2020Article
- Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample.Frontiers in psychiatry · 2019Article
- Common Factors in Pediatric Psychiatry: A Review of Essential and Adjunctive Mechanisms of Treatment Outcome.Journal of child and adolescent psychopharmacology · 2017Review
- Pharmacotherapy for Pediatric Generalized Anxiety Disorder: A Systematic Evaluation of Efficacy, Safety and Tolerability.Paediatric drugs · 2016Review
- The role of co-occurring disruptive behavior in the clinical presentation of children and adolescents with anxiety in the context of autism spectrum disorders.Child psychiatry and human development · 2012Article
- Advances in the treatment of pediatric obsessive-compulsive d-cycloserine with exposure and response prevention.Neuropsychiatry · 2012Article
- Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine.Molecular brain · 2011Article
- Evidence-based pharmacotherapy for pediatric obsessive-compulsive disorder and chronic tic disorders.Journal of central nervous system disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectivesThis article reviews evidence that led the Food and Drug Administration to issue a "black box" warning about the risk of "suicidality" (suicidal thoughts and behavior) in children and adolescents during treatment with antidepressants.
resultsRe-analysis of data from randomized clinical trials of antidepressants in the pediatric population revealed a significantly greater overall (all drugs across all indications) risk ratio for drug 1.95 (95% Cl, 1.28-2.98) compared to placebo in this sample of approximately 4,000 subjects. DISCUSSION: The essential message of the "black box" is to remind prescribers and consumers about the importance of monitoring closely for adverse behavioral changes during the initiation of (or changes in) antidepressant therapy. Possible mechanisms that might account for this phenomenon, particularly the so-called activation syndrome, are discussed.
conclusionEmpirical studies are needed to identify the precursors of suicidality and to predict which individuals are most susceptible to adverse behavioral side effects of antidepressants.
Indexed as
Identifiers
17180618What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.