Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis.PloS one · 2022
   Pooled it
2. The composition of single-donor apheresis platelet concentrates is influenced by the age of the donor.Scientific reports · 2025
   Article
3. Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review.Frontiers in cardiovascular medicine · 2023
   Review
4. Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context.Microorganisms · 2022
   Article
5. Platelets as Key Factors in Inflammation: Focus on CD40L/CD40.Frontiers in immunology · 2022
   Review
6. Platelet Innate Immune Receptors and TLRs: A Double-Edged Sword.International journal of molecular sciences · 2021
   Review
7. A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection.Seminars in thrombosis and hemostasis · 2020
   Review
8. Platelets can reflect the severity of Crohn's disease without the effect of anemia.Clinics (Sao Paulo, Brazil) · 2020
   Article
9. Translational Implications of Platelets as Vascular First Responders.Circulation research · 2018
   Review
10. Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation.Frontiers in immunology · 2018
    Review
11. NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets.Frontiers in immunology · 2017
    Article
12. Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis.Mediators of inflammation · 2017
    Review
13. Platelets in infectious disease.Hematology. American Society of Hematology. Education Program · 2016
    Review
14. Platelet-neutrophil interactions under thromboinflammatory conditions.Cellular and molecular life sciences : CMLS · 2015
    Review
15. Platelets and infections - complex interactions with bacteria.Frontiers in immunology · 2015
    Review
16. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.Circulation. Cardiovascular genetics · 2014
    Article
17. Multipotent role of platelets in inflammatory bowel diseases: a clinical approach.World journal of gastroenterology · 2014
    Review
18. Oral contraceptives and nicotine synergistically exacerbate cerebral ischemic injury in the female brain.Translational stroke research · 2013
    Article
19. Platelets and the immune continuum.Nature reviews. Immunology · 2011
    Review
20. Platelets as immune mediators: their role in host defense responses and sepsis.Thrombosis research · 2011
    Review

Corrections and comments

• Comment on
  Platelet and soluble CD40L in meningococcal sepsis.2006

Authors and funding

5 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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