ArticleMolecular psychiatry2007
Interleukin 3 and schizophrenia: the impact of sex and family history.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- IL-3: key orchestrator of inflammation.Frontiers in immunology · 2024Review
- Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment.Frontiers in psychiatry · 2021Review
- Role of the β Common (βc) Family of Cytokines in Health and Disease.Cold Spring Harbor perspectives in biology · 2018Review
- Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations.Human genetics · 2016Article
- Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia.Biological psychiatry · 2013Review
- Immune system gene dysregulation in autism and schizophrenia.Developmental neurobiology · 2012Review
- Article
- Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.Schizophrenia research · 2011Article
- Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia--a case-control study.Journal of molecular neuroscience : MN · 2010Article
- Schizophrenia gene networks and pathways and their applications for novel candidate gene selection.PloS one · 2010Article
- Nature and nurture in neuropsychiatric genetics: where do we stand?Dialogues in clinical neuroscience · 2010Review
- The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.Schizophrenia research · 2009Article
- Apoptotic engulfment pathway and schizophrenia.PloS one · 2009Article
- Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study.Current pharmacogenomics and personalized medicine · 2009Article
- Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence.Archives of general psychiatry · 2009Article
- The validity of the family history screen for assessing family history of mental disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study.Psychological medicine · 2008Article
- Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.Schizophrenia research · 2008Article
- Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?Schizophrenia research · 2008Article
- FBXL21 association with schizophrenia in Irish family and case-control samples.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Chromosome 5q21-33 has been implicated in harboring risk genes for schizophrenia. In this paper, we report evidence that multiple single nucleotide polymorphisms in and around interleukin 3 (IL3) are associated with the disease in the Irish Study of High-Density Schizophrenia Families (ISHDSF), the Irish Case-Control Study of Schizophrenia (ICCSS) and the Irish Trio Study of Schizophrenia (ITRIO). The associations are sex-specific and depend on the family history (FH) of schizophrenia. In all three samples, rs31400 shows female-specific and FH-dependent associations (P=0.0062, 0.0647 and 0.0284 for the ISHDSF, ICCSS and ITRIO, respectively). Several markers have similar associations in one or two of the three samples. In haplotype analyses, identical risk and protective haplotypes are identified in the ISHDSF and ITRIO samples in several multimarker combinations. For ICCSS, the same haplotypes are implicated; however, the risk haplotypes observed in the family samples become protective. Several significant markers, rs440970, rs31400 and rs2069803, are located in and around known estrogen response elements, promoter and enhancer of the IL3 gene. They may explain the sex-specific associations and be functional for the expression of IL3 gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.