ArticleBritish journal of pharmacology2007
n-3 (omega-3) polyunsaturated fatty acids prevent acute atrial electrophysiological remodeling.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- The beneficial effects of omega-3 polyunsaturated fatty acids on controlling blood pressure: An umbrella meta-analysis.Frontiers in nutrition · 2022Pooled it
- The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.Physiological reviews · 2026Review
- Fish oil supplements in patients with chronic kidney disease.Clinical kidney journal · 2026Review
- Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.The journal of physiological sciences : JPS · 2025Article
- Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults.Journal of hypertension · 2018Article
- A meta-analysis on Omega-3 supplements in preventing recurrence of atrial fibrillation.Oncotarget · 2018Article
- Omega 3 and atrial fibrillation: Where are we?World journal of cardiology · 2016Article
- Upstream Treatment of Atrial Fibrillation with n-3 Polyunsaturated Fatty Acids: Myth or Reality?Arrhythmia & electrophysiology review · 2015Article
- The Current Role of Omega-3 Fatty Acids in the Management of Atrial Fibrillation.International journal of molecular sciences · 2015Review
- Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women.The Journal of nutrition · 2015Observational
- Omega-3 PUFAs and atrial fibrillation: have we made up our mind yet?Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2013Review
- Omega-3 Polyunsaturated Fatty Acid Supplementation: Mechanism and Current Evidence in Atrial Fibrillation.Journal of atrial fibrillation · 2012Review
- FISHing for Answers in Postoperative Atrial Fibrillation.Journal of the American Heart Association · 2012Article
- Polyunsaturated Fatty acids in atrial fibrillation: looking for the proper candidates.Frontiers in physiology · 2012Article
- Fish, Marine n-3 Fatty Acids, and Atrial Fibrillation - Experimental Data and Clinical Effects.Frontiers in physiology · 2012Article
- Eicosapentaenoic acid for the prevention of recurrent atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2011Article
- Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.Cardiovascular research · 2011Article
- Vagal nerve stimulation in prevention and management of coronary heart disease.World journal of cardiology · 2011Article
- Primary and secondary prevention of atrial fibrillation with statins and polyunsaturated fatty acids: review of evidence and clinical relevance.Naunyn-Schmiedeberg's archives of pharmacology · 2010Review
- Omega-3 fatty acids and heart failure.Current atherosclerosis reports · 2009Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeRecent reports suggest that n-3 (omega-3) polyunsaturated fatty acids (PUFAs) may reduce atrial fibrillation (AF). Reduction of the atrial effective refractory period (ERP) is believed to be an important early remodeling event that favors the development and perpetuation of AF. We hypothesized that n-3 PUFAs would attenuate early atrial electrophysiolgical remodeling in a canine model of acute atrial tachypacing. EXPERIMENTAL APPROACH: Adult dogs of either sex received n-3 PUFAs (n=6), n-6 PUFAs (n=6), or saline (n=6) infused over 1 h. After a stable ERP was established, treatment was initiated concurrently with 6 h of rapid atrial pacing (400 b.p.m.). Serial right atrial ERPs were measured during rapid atrial pacing, and induction of atrial tachyarrhythmias was attempted at the conclusion of each study. KEY
resultsThere was no change in P wave duration or in the PQ, QRS, QT or QTc intervals in any of the treatment groups. N-3 PUFA treatment significantly reduced the shortening of atrial ERP, compared to both control groups (P<0.05). In separate experiments, the same n-3 PUFA infusion was given to dogs remaining in normal sinus rhythm. During sinus rhythm, n-3 PUFA infusion did not alter any electrocardiogram (ECG) parameter or the atrial ERP. CONCLUSIONS AND IMPLICATIONS: We conclude that acute n-3 PUFA treatment prevents acute atrial electrophysiological remodeling during high rate activity, which may minimize the self-perpetuation of AF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.