ArticleBritish journal of pharmacology2007
Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for 'lost proteins'?
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Single-cell mapping of human plasma cell fate reveals a commitment checkpoint and Cav-1β expression associated with mTORC1 machinery.iScience · 2026Article
- The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases.Frontiers in physiology · 2020Review
- Caveolins as Regulators of Stress Adaptation.Molecular pharmacology · 2018Review
- Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells.Molecular neurobiology · 2018Article
- Caveolae: A Role in Endothelial Inflammation and Mechanotransduction?Frontiers in physiology · 2016Review
- Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.Anesthesiology · 2014Article
- Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1.American journal of physiology. Cell physiology · 2013Article
- Caveolae, caveolins, cavins, and endothelial cell function: new insights.Frontiers in physiology · 2012Article
- Lipid rafts and caveolae and their role in compartmentation of redox signaling.Antioxidants & redox signaling · 2009Review
- Lipid raft in cardiac health and disease.Current cardiology reviews · 2009Article
- Caveolin-1: an ambiguous partner in cell signalling and cancer.Journal of cellular and molecular medicine · 2008Review
- Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes.Cell communication & adhesion · 2008Article
- Caveolae as organizers of pharmacologically relevant signal transduction molecules.Annual review of pharmacology and toxicology · 2008Review
- Organizational principles of the connexin-related brain transcriptome.The Journal of membrane biology · 2007Article
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Abstract
A wide array of phenotypic changes have been reported in mice with knockout of expression of caveolin-1. Neidhold et al. (2007) describe results in this issue that continue this trend by showing that saphenous arteries from adult caveolin-1 knockout mice lack caveolae, lose beta1-adrenoceptor-promoted relaxation, gain beta3-adrenoceptor-promoted relaxation but show no change in vasomotor response to beta2-adrenoceptor activation. Neither the physiological importance for wild-type animals nor the mechanistic basis for these changes is clear. Although the caveolin-1 knockout and wild-type mice express similar levels of the receptor mRNAs, the protein expression of the receptors is not specified and represents, in our view, an important limitation of the study. We also question the physiological relevance of the findings and ask: Do studies in total body/lifespan caveolin-knockout mice further understanding of physiology and pharmacology or do they primarily characterize secondary consequences? We propose that alternative approaches that decrease caveolin expression in a temporally and spatially discrete manner are more likely to facilitate definitive conclusions regarding caveolin-1 and its role in regulation of beta-adrenoceptors and other pharmacological targets.
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