ArticleProceedings of the National Academy of Sciences of the United States of America1991
Dual activation of a sex pheromone-dependent ion channel from insect olfactory dendrites by protein kinase C activators and cyclic GMP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 108 citations in OpenAlex.
- A chromosome-level genome assembly of the pollinating fig wasp Valisia javana.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- The structure of Orco and its impact on our understanding of olfaction.The Journal of general physiology · 2018Article
- The Diacylglycerol Analogs OAG and DOG Differentially Affect Primary Events of Pheromone Transduction in the HawkmothFrontiers in cellular neuroscience · 2018Article
- Extracellular modulation of the silkmoth sex pheromone receptor activity by cyclic nucleotides.PloS one · 2014Article
- Kinetics of olfactory responses might largely depend on the odorant-receptor interaction and the odorant deactivation postulated for flux detectors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Review
- Dynamical modeling of the moth pheromone-sensitive olfactory receptor neuron within its sensillar environment.PloS one · 2011Article
- Optogenetically Induced Olfactory Stimulation in Drosophila Larvae Reveals the Neuronal Basis of Odor-Aversion behavior.Frontiers in behavioral neuroscience · 2010Article
- Pheromone transduction in moths.Frontiers in cellular neuroscience · 2010Article
- Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system.Current opinion in neurobiology · 2009Review
- Computational model of the insect pheromone transduction cascade.PLoS computational biology · 2009Article
- Odorant and pheromone receptors in insects.Frontiers in cellular neuroscience · 2009Article
- Cell responses to single pheromone molecules may reflect the activation kinetics of olfactory receptor molecules.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2003Article
- Presence of long-lasting peripheral adaptation in oblique-banded leafroller, Choristoneura rosaceana and absence of such adaptation in redbanded leafroller, Argyrotaenia velutinana.Journal of chemical ecology · 2003Article
- Transduction ion channels directly gated by sugars on the insect taste cell.The Journal of general physiology · 2000Article
- Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Dendritic integration in olfactory sensory neurons: a steady-state analysis of how the neuron structure and neuron environment influence the coding of odor intensity.Journal of computational neuroscience · 1998Article
- Identification of a long-lasting form of odor adaptation that depends on the carbon Monoxide/cGMP second-messenger system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Synergism of an insect sex pheromone specialist neuron: Implications for component identification and receptor interactions.Journal of chemical ecology · 1995Article
- Regulation of calcium-activated nonselective cation channel activity by cyclic nucleotides in the rat insulinoma cell line, CRI-G1.The Journal of membrane biology · 1995Article
- Requirement for a phospholipase C in odor response: overlap between olfaction and vision in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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2 authors at 1 institution in 1 country.
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Abstract
Olfactory transduction is thought to take place in the outer dendritic membrane of insect olfactory receptor neurons. Here we show that the outer dendritic plasma membrane of silkmoth olfactory receptor neurons seems to be exclusively equipped with a specific ion channel activated by low concentrations of the species-specific sex pheromone component. This so-called AC1 channel has a conductance of 56 pS and is nonselectively permeable to cations. The AC1 channel can be activated from the intracellular side by protein kinase C activators such as diacylglycerol and phorbolester and by cGMP but not by Ca2+, inositol 1,4,5-triphosphate, or cAMP. Our results imply that phosphorylation of this ion channel by protein kinase C could be the crucial step in channel opening by sex pheromones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.