ArticleProceedings of the National Academy of Sciences of the United States of America1991
Coexpression of alpha 1 with putative beta 3 subunits results in functional Na+/K+ pumps in Xenopus oocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Endogenous cardiotonic steroids and cardiovascular disease, where to next?Cell calcium · 2020Review
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- Mineralocorticoids modulate the expression of the β-3 subunit of the NaChannels (Austin, Tex.) · 2017Article
- Article
- Regulation of the cardiac sodium pump.Cellular and molecular life sciences : CMLS · 2013Review
- A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.The EMBO journal · 2002Article
- Functional differences between alpha subunit isoforms of the rat Na,K-ATPase expressed in Xenopus oocytes.The Journal of physiology · 2002Article
- Voltage dependence of the apparent affinity for external Na(+) of the backward-running sodium pump.The Journal of general physiology · 2001Article
- Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes.Molecular biology of the cell · 1998Article
- Na,K-ATPase subunit beta1 knock-in prevents lethality of beta2 deficiency in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Role in cation translocation of the N-terminus of the alpha-subunit of the Na(+)-K+ pump of Bufo.The Journal of physiology · 1996Article
- Modulation of the Na,K-pump function by beta subunit isoforms.The Journal of general physiology · 1994Article
- Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps.The Journal of cell biology · 1993Article
- Mechanisms of urinary K+ and H+ excretion: primary structure and functional expression of a novel H,K-ATPase.The Journal of cell biology · 1993Article
- Primary sequence and functional expression of a novel beta subunit of the P-ATPase gene family.Pflugers Archiv : European journal of physiology · 1993Article
- Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity.The Journal of cell biology · 1992Article
- Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.The EMBO journal · 1992Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The active Na+/K+ pump is composed of an alpha and a beta subunit. Until now, three putative isoforms of the beta subunit have been identified that share sequence similarity. We have expressed the beta 1 and beta 3 isoforms of Xenopus laevis Na+/K(+)-ATPase in Xenopus oocytes to compare functional properties of the Na+/K+ pump, including either of these two isoforms. Na+/K+ pump current, estimated as K(+)-induced outward current in voltage-clamped oocytes, was doubled by coexpression of alpha 1 subunits with either isoform of the beta subunit compared to expression of alpha 1 subunits alone. The kinetics of activation by external K+ and the voltage dependence of the electrogenic activity of the Na+/K+ pump were similar with both beta isoforms, indicating that both beta 1 and beta 3 isoforms can support expression at the oocyte surface of an active Na+/K+ pump with similar functional properties.
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