ArticleJournal of Korean medical science2006
Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia.
Article in Journal of Korean medical science, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis.Scientific reports · 2016Pooled it
- Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.Frontiers in immunology · 2025Article
- Review
- Interrelationship between Toll-like receptors and infection after orthotopic liver transplantation.World journal of transplantation · 2020Review
- Association of TLR4 gene polymorphisms with childhood Henoch-Schönlein purpura in a Chinese population.Rheumatology international · 2017Article
- Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.Immunologic research · 2015Review
- Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer.Genes and immunity · 2014Review
- Association of Toll-like receptor 2 polymorphisms with gout.Biomedical reports · 2014Article
- Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.TheScientificWorldJournal · 2013Article
- Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins.Infection and immunity · 2012Article
- Innate immune recognition of Mycobacterium tuberculosis.Clinical & developmental immunology · 2011Review
- Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.Journal of hepatology · 2009Article
- TLR2 polymorphisms, Arg753Gln and Arg677Trp, are not associated with increased burden of tuberculosis in Indian patients.BMC research notes · 2009Article
- Rarity of TLR4 Asp299Gly and Thr399Ile polymorphisms in the Korean population.Yonsei medical journal · 2008Article
- TLR and MBL gene polymorphisms in severe acute pancreatitis.Molecular diagnosis & therapy · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
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