ArticleThe British journal of ophthalmology2007
Human papillomavirus and pterygium. Is the virus a risk factor?
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.International ophthalmology · 2023Article
- Article
- Application of a Deep Learning System in Pterygium Grading and Further Prediction of Recurrence with Slit Lamp Photographs.Diagnostics (Basel, Switzerland) · 2022Article
- Advances in artificial intelligence applications for ocular surface diseases diagnosis.Frontiers in cell and developmental biology · 2022Review
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- human adenoviruses role in ophthalmic pterygium formation.Jundishapur journal of microbiology · 2015Article
- Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review).International journal of molecular medicine · 2013Review
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.Eye (London, England) · 2012Review
- HPV infection and p53 inactivation in pterygium.Molecular vision · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPterygium is a disease of unknown origin and pathogenesis that might be vision threatening. It is characterised by a wing-like conjunctival overgrowth of the cornea. Several studies have investigated human papillomavirus (HPV) as a risk factor for the development of pterygia, but the results are inconclusive.
aimTo investigate a large sample of pterygia for the presence of HPV in order to clarify the putative association between pterygia and HPV.
methods100 specimens of pterygium from Danish patients and 20 normal conjunctival biopsy specimens were investigated for the presence of HPV with PCR technique using beta-globin primers to access the quality of the extracted DNA and the HPV primers MY09/11 and GP5+/6+. HPV-positive specimens underwent subsequent HPV typing with type-specific HPV primers and further investigation with DNA in situ hybridisation (ISH).
results90 of 100 investigated pterygia proved suitable for HPV analysis by PCR. As beta-globin could not be amplified, 10 specimens were excluded from the study. 4 of 90 pterygia harboured HPV. HPV type 6 was identified in all four HPV-positive pterygia. The 20 normal conjunctival biopsy specimens were beta-globin positive and HPV negative. All four pterygia that were HPV type 6 positive were DNA ISH negative.
conclusionsThe low presence of HPV DNA in pterygia does not support the hypothesis that HPV is involved in the development of pterygia in Denmark.
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