ArticleThe British journal of ophthalmology2007
Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Therapeutic Potential of Graphene Quantum Dots on Pterygium Cells.Investigative ophthalmology & visual science · 2025Article
- Z-shaped incision without epithelial resection in pterygium surgery.International journal of ophthalmology · 2024Article
- Synergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis.International journal of molecular sciences · 2023Article
- A case of pterygium-like proliferation containing postoperative limbal dermoid remnants: a clinicopathological study.BMC ophthalmology · 2021Article
- Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus.Beyoglu eye journal · 2020Article
- Overexpression of fractalkine and its histopathological characteristics in primary pterygium.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Pterygial body epithelium domination of pterygial proliferation with TCF4 as a potential key factor.International journal of ophthalmology · 2018Article
- MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway.Molecular vision · 2018Article
- How to minimize pterygium recurrence rates: clinical perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2018Review
- Current approaches and future directions in the management of pterygium.International journal of ophthalmology · 2018Article
- SERPINA3K plays antioxidant roles in cultured pterygial epithelial cells through regulating ROS system.PloS one · 2014Article
- MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis.Molecular vision · 2014Article
- EphB4 expression in pterygium is associated with microvessel density.International journal of clinical and experimental medicine · 2014Article
- Immunohistochemical detection of Hsp90 and Ki-67 in pterygium.Diagnostic pathology · 2013Article
- Expression of vascular endothelial growth factor C in human pterygium.Histochemistry and cell biology · 2013Article
- Increased importin 13 activity is associated with the pathogenesis of pterygium.Molecular vision · 2013Article
- WW Domain Containing Transcription Regulator regulates human conjunctiva epithelial cell proliferation via inhibiting TGFβ signaling pathway [corrected].Molecular vision · 2012Article
- Tissue factor expression in human pterygium.Molecular vision · 2011Article
- Expression of cell proliferation and apoptosis biomarkers in pterygia and normal conjunctiva.Molecular vision · 2011Article
- CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization.Molecular vision · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pterygium is a growth onto the cornea of fibrovascular tissue that is continuous with the conjunctiva, whereas the mechanisms of cell proliferation in pterygium epithelium are unknown.
aimTo analyse the histopathology and the expression of cell cycle-related molecules in pterygium tissues.
methodsSeven pterygia were surgically removed using the bare-sclera procedure, and three normal bulbar conjunctivas were also obtained. Formalin-fixed, paraffin-wax-embedded tissues were analysed by immunohistochemistry with anti-p27(KIP1), cyclin D1 and Ki-67 antibodies.
resultsConjunctival epithelium consisted of several layers of round cells with a few goblet cells. Nuclear immunoreactivity for p27(KIP1) was noted in many normal epithelial cells, where cyclin D1 and Ki-67-positive nuclei were intermingled. A variety of goblet cells were located in the superficial layer of the pterygium head as well as those of the body epithelia. Several pterygium epithelial cells were p27(KIP1) positive, whereas nuclear immunoreactivity for cyclin D1 and Ki-67 was detected in many epithelial cells. By contrast, immunoreactivity for p27(KIP1), cyclin D1 and Ki-67 was hardly detected in the pterygium stroma.
conclusionIt is suggested that pterygium growth and development are associated with the proliferation of epithelium, which is possibly involved in the expression of cell cycle-related molecules.
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