SynthesisGenetics2007
G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies.
Synthesis in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.Human genetics · 2012Pooled it
- Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.Biological psychiatry · 2011Pooled it
- Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.Schizophrenia research · 2008Pooled it
- Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations.Biomolecules · 2022Review
- d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.International journal of molecular sciences · 2021Review
- Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.Brain imaging and behavior · 2021Article
- Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders.Biological psychiatry · 2017Article
- The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies.NPJ schizophrenia · 2017Review
- Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation.Scientific reports · 2016Article
- G72 primate-specific gene: a still enigmatic element in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2016Review
- Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.European archives of psychiatry and clinical neuroscience · 2015Article
- Reviewing the ketamine model for schizophrenia.Journal of psychopharmacology (Oxford, England) · 2014Review
- Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia.Schizophrenia bulletin · 2012Review
- N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Contribution of nonprimate animal models in understanding the etiology of schizophrenia.Journal of psychiatry & neuroscience : JPN · 2011Review
- Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals.Human brain mapping · 2011Article
- Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.Psychopharmacology · 2011Article
- Thinking glutamatergically: changing concepts of schizophrenia based upon changing neurochemical models.Clinical schizophrenia & related psychoses · 2010Review
- The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach.BMC psychiatry · 2010Article
- G72 influences longitudinal change in frontal lobe volume in schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Schizophrenia may result from a neurotransmission hypofunction of glutamatergic and N-methyl-d-aspartate (NMDA) receptors. Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and d-amino-acid oxidase (DAAO) genes. Since the first positive association report, many subsequent studies have attempted to replicate the association but the results have been mixed. To try to resolve this inconsistency and to elucidate the relationship between the important glutamate-related genes and schizophrenia, the current meta-analysis has combined samples involving 16 polymorphisms covering all published case-control and family-based association studies up to October 2005. The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.