ArticleGenetics2007
Natural variation in the Pto disease resistance gene within species of wild tomato (Lycopersicon). II. Population genetics of Pto.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- Patterns of presence-absence variation of NLRs across populations of Solanum chilense are clade-dependent and mainly shaped by past demographic history.The New phytologist · 2025Article
- Inference of coevolutionary dynamics and parameters from host and parasite polymorphism data of repeated experiments.PLoS computational biology · 2020Article
- The evolutionary history of LysM-RLKs (LYKs/LYRs) in wild tomatoes.BMC evolutionary biology · 2019Article
- The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant⁻Microbe Interactions.Genes · 2019Review
- Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/The Plant cell · 2017Article
- Promoter variants of Xa23 alleles affect bacterial blight resistance and evolutionary pattern.PloS one · 2017Article
- The wild tomato speciesPeerJ · 2017Article
- Pooled Enrichment Sequencing Identifies Diversity and Evolutionary Pressures at NLR Resistance Genes within a Wild Tomato Population.Genome biology and evolution · 2016Article
- Genome-Wide Analysis and Evolution of the Pto-Like Protein Kinase (PLPK) Gene Family in Pepper.PloS one · 2016Article
- Nucleotide diversity analysis of three major bacterial blight resistance genes in rice.PloS one · 2015Article
- Kinase domain-targeted isolation of defense-related receptor-like kinases (RLK/Pelle) in Platanus×acerifolia: phylogenetic and structural analysis.BMC research notes · 2014Article
- Genomic variability as a driver of plant-pathogen coevolution?Current opinion in plant biology · 2014Review
- Article
- Isolation and diversity analysis of resistance gene homologues from switchgrass.G3 (Bethesda, Md.) · 2013Article
- Nonhost resistance of tomato to the bean pathogen Pseudomonas syringae pv. syringae B728a is due to a defective E3 ubiquitin ligase domain in avrptobb728a.Molecular plant-microbe interactions : MPMI · 2013Article
- Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella.BMC evolutionary biology · 2012Article
- Genetic and genomic approaches for R-gene mediated disease resistance in tomato: retrospects and prospects.Plant cell reports · 2012Review
- Parallel Loss-of-Function at the RPM1 Bacterial Resistance Locus in Arabidopsis thaliana.Frontiers in plant science · 2012Article
- Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disease resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) in the host species Lycopersicon esculentum, the cultivated tomato, and the closely related L. pimpinellifolium is triggered by the physical interaction between the protein products of the host resistance (R) gene Pto and the pathogen avirulence genes AvrPto and AvrPtoB. Sequence variation at the Pto locus was surveyed in natural populations of seven species of Lycopersicon to test hypotheses of host-parasite coevolution and functional adaptation of the Pto gene. Pto shows significantly higher nonsynonymous polymorphism than 14 other non-R-gene loci in the same samples of Lycopersicon species, while showing no difference in synonymous polymorphism, suggesting that the maintenance of amino acid polymorphism at this locus is mediated by pathogen selection. Also, a larger proportion of ancestral variation is maintained at Pto as compared to these non-R-gene loci. The frequency spectrum of amino acid polymorphisms known to negatively affect Pto function is skewed toward low frequency compared to amino acid polymorphisms that do not affect function or silent polymorphisms. Therefore, the evolution of Pto appears to be influenced by a mixture of both purifying and balancing selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.