ArticleThe Journal of experimental medicine2006
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 111 citations in OpenAlex.
- Features of B Cell Responses Relevant to Allergic Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.The Journal of experimental medicine · 2020Article
- Curcumin Regulated the Homeostasis of Memory T Cell and Ameliorated Dextran Sulfate Sodium-Induced Experimental Colitis.Frontiers in pharmacology · 2020Article
- T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma.Frontiers in immunology · 2019Review
- Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females.International journal of molecular sciences · 2018Review
- Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.Frontiers in immunology · 2018Review
- B Cell Intrinsic Mechanisms Constraining IgE Memory.Frontiers in immunology · 2017Review
- Mycobacterium vaccae Nebulization Can Protect against Asthma in Balb/c Mice by Regulating Th9 Expression.PloS one · 2016Article
- Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production.European journal of immunology · 2016Article
- Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.Journal of gastroenterology · 2015Article
- Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins.Oncotarget · 2015Article
- Article
- Cytokine crowdsourcing: multicellular production of TH17-associated cytokines.Journal of leukocyte biology · 2015Review
- Activation of invariant natural killer T cells in regional lymph nodes as new antigen-specific immunotherapy via induction of interleukin-21 and interferon-γ.Clinical and experimental immunology · 2014Article
- IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection.PloS one · 2014Article
- Effects of mycobacteria major secretion protein, Ag85B, on allergic inflammation in the lung.PloS one · 2014Article
- The unique features of follicular T cell subsets.Cellular and molecular life sciences : CMLS · 2013Review
- The emerging role of interleukin-21 in allergic diseases (Review).Biomedical reports · 2013Article
- IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma.Clinical & translational immunology · 2013Article
- The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.Immunity · 2013Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have suggested that the recent increase in the incidence and severity of immunoglobulin (Ig)E-mediated allergic disorders is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination; however, the underlying mechanisms remain uncertain. Here, we demonstrate that natural killer T (NKT) cells in mice and humans play a crucial role in the BCG-induced suppression of IgE responses. BCG-activated murine Valpha14 NKT cells, but not conventional CD4 T cells, selectively express high levels of interleukin (IL)-21, which preferentially induces apoptosis in Bepsilon cells. Signaling from the IL-21 receptor increases the formation of a complex between Bcl-2 and the proapoptotic molecule Bcl-2-modifying factor, resulting in Bepsilon cell apoptosis. Similarly, BCG vaccination induces IL-21 expression by human peripheral blood mononuclear cells (PBMCs) in a partially NKT cell-dependent fashion. BCG-activated PBMCs significantly reduce IgE production by human B cells. These findings provide new insight into the therapeutic effect of BCG in allergic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.