ArticleThe Journal of cell biology2006
Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity.Mechanobiology in medicine · 2025Article
- Relationship of Neurotropin-3 Gene Polymorphism with Cognitive Impairment in Bipolar Disorder.Indian journal of psychological medicine · 2025Article
- Neurotrophin-3 Rescues Striatal Synaptic Plasticity in Model of Neurodegeneration by PLC Signaling Activation.CNS & neurological disorders drug targets · 2024Article
- Electroacupuncture Facilitates the Integration of Neural Stem Cell-Derived Neural Network with Transected Rat Spinal Cord.Stem cell reports · 2019Article
- Neurotrophin-3 provides neuroprotection via TrkC receptor dependent pErk5 activation in a rat surgical brain injury model.Experimental neurology · 2018Article
- Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats.Molecular neurobiology · 2018Article
- Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease.CNS neuroscience & therapeutics · 2018Article
- Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
- Reconstitution of Giant Mammalian Synapses in Culture for Molecular Functional and Imaging Studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neurotrophin regulation of neural circuit development and function.Nature reviews. Neuroscience · 2013Review
- Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation.Molecular brain · 2011Article
- Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway.Molecular biology of the cell · 2009Article
- Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses.The Journal of cell biology · 2009Article
- Complementary actions of BDNF and neurotrophin-3 on the firing patterns and synaptic composition of motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2.Molecular and cellular biology · 2008Article
- Selective targeting of different neural cell adhesion molecule isoforms during motoneuron myotube synapse formation in culture and the switch from an immature to mature form of synaptic vesicle cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The mechanisms by which neurotrophins elicit long-term structural and functional changes of synapses are not known. We report the mechanistic separation of functional and structural synaptic regulation by neurotrophin 3 (NT-3), using the neuromuscular synapse as a model. Inhibition of cAMP response element (CRE)-binding protein (CREB)-mediated transcription blocks the enhancement of transmitter release elicited by NT-3, without affecting the synaptic varicosity of the presynaptic terminals. Further analysis indicates that CREB is activated through Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) pathway, rather than the mitogen-activated protein kinase (MAPK) or cAMP pathway. In contrast, inhibition of MAPK prevents the NT-3-induced structural, but not functional, changes. Genetic and imaging experiments indicate that the small GTPase Rap1, but not Ras, acts upstream of MAPK activation by NT-3. Thus, NT-3 initiates parallel structural and functional modifications of synapses through the Rap1-MAPK and CaMKIV-CREB pathways, respectively. These findings may have implications in the general mechanisms of long-term synaptic modulation by neurotrophins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.