ArticleInfection and immunity2007
Coactivating signals for the hepatic lymphocyte gamma interferon response to Francisella tularensis.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Complement C3 as a Prompt for Human Macrophage Death during Infection with Francisella tularensis Strain SCHU S4.Infection and immunity · 2017Article
- FeoB-mediated uptake of iron by Francisella tularensis.Infection and immunity · 2013Article
- Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia.Infection and immunity · 2012Article
- Systemic response to Campylobacter jejuni infection by profiling gene transcription in the spleens of two genetic lines of chickens.Immunogenetics · 2012Article
- Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.Microbiology and molecular biology reviews : MMBR · 2009Review
- Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice.Infection and immunity · 2009Article
- Programmed cell death and the pathogenesis of tissue injury induced by type A Francisella tularensis.FEMS microbiology letters · 2009Review
- T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria.Infection and immunity · 2009Article
- Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate.Journal of veterinary science · 2008Article
- Diverse myeloid and lymphoid cell subpopulations produce gamma interferon during early innate immune responses to Francisella tularensis live vaccine strain.Infection and immunity · 2008Article
- NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain.Infection and immunity · 2008Article
- Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytes.Infection and immunity · 2007Article
- Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.Immunology letters · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The facultative intracellular bacterium Francisella tularensis is capable of causing systemic infections in various hosts, including mice and humans. The liver is a major secondary site of F. tularensis infection, but hepatic immune responses to the pathogen remain poorly defined. Immune protection against the pathogen is thought to depend on the cytokine gamma interferon (IFN-gamma), but the cellular basis for this response has not been characterized. Here we report that natural killer cells from the livers of naïve uninfected mice produced IFN-gamma when challenged with live bacteria in vitro and that the responses were greatly increased by coactivation of the cells with either recombinant interleukin-12 (IL-12) or IL-18. Moreover, the two cytokines had strong synergistic effects on IFN-gamma induction. Neutralizing antibodies to either IL-12 or IL-18 inhibited IFN-gamma production in vitro, and mice deficient in the p35 subunit of IL-12 failed to show IFN-gamma responses to bacterial challenge either in vitro or in vivo. Clinical isolates of highly virulent type A Francisella tularensis subsp. tularensis organisms were comparable to the live attenuated vaccine strain of Francisella tularensis subsp. holarctica in their ability to induce IL-12 and IFN-gamma expression. These findings demonstrate that cells capable of mounting IFN-gamma responses to F. tularensis are resident within the livers of uninfected mice and depend on coactivation by IL-12 and IL-18 for optimum responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.