ArticleBMC evolutionary biology2006
Insights on the evolution of trehalose biosynthesis.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers.
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203 citing papers in PubMed, 506 citations in OpenAlex.
- UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci.Journal of advanced research · 2026Article
- Trehalose: a multifunctional sugar and its metabolites are biotechnological targets for crop salinity tolerance under saline conditions.Plant molecular biology · 2026Review
- Functional Analysis of Adipokinetic Hormone and Its Receptor Genes in Regulating Energy Metabolism Under Stress Conditions inInternational journal of molecular sciences · 2026Article
- Identification, expression profiling, and functional characterization of trehalase genes (OaTRE1 and OaTRE) in Oedaleus asiaticus (Orthoptera: Acridoidea).Journal of insect science (Online) · 2026Article
- Conserved storage-carbohydrate metabolic modules are rewired during germination ofFrontiers in fungal biology · 2026Article
- Alkane-oxidizing consortia produce substantial amounts of disaccharides.Frontiers in microbiology · 2026Article
- Genome-wide identification and expression analysis ofFrontiers in plant science · 2026Article
- Dose-response-defined physiological framework enables comparative analysis of transcriptional response dynamics across multiple herbicides inFrontiers in plant science · 2026Article
- Intercellular compartmentation of trehalose 6-phosphate metabolism in Setaria viridis leaves.Journal of experimental botany · 2025Article
- Characterization of trehalose-6-phosphate synthase gene family in linseed (Linum usitatissimum L.) and its potential implications in flowering time regulation.BMC plant biology · 2025Article
- Genome-Wide Analysis of Trehalose-6-Phosphate Phosphatases (TPP) Gene Family in Potato (Plants (Basel, Switzerland) · 2025Article
- The role of trehalose metabolism in plant stress tolerance.Journal of advanced research · 2025Review
- Transcriptomic Analysis of Osmotic Stress-Tolerant Somatic Embryos ofInternational journal of molecular sciences · 2025Article
- Article
- Effects of Trehalase on the Gene Expression of the Reproductive Regulation Pathway Network and Triglyceride Metabolism inInsects · 2025Article
- Transcriptome Analysis Reveals the Role of Trehalose in Response to Polyethylene Terephthalate Nanoplastics Treatment in Foxtail Millet (Food science & nutrition · 2025Article
- The synthesis, degradation and biological function of trehalose- 6-phosphate.Stress biology · 2025Review
- Sugar-sensing swodkoreceptors and swodkocrine signaling.Animal models and experimental medicine · 2025Article
- Evolution and amplification of the trehalose-6-phosphate synthase gene family in Theaceae.BMC genomics · 2025Article
- Unveiling the thermotolerance mechanism of Pichia kudriavzevii LC375240 through transcriptomic and genetic analyses.BMC biology · 2025Article
143 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe compatible solute trehalose is a non-reducing disaccharide, which accumulates upon heat, cold or osmotic stress. It was commonly accepted that trehalose is only present in extremophiles or cryptobiotic organisms. However, in recent years it has been shown that although higher plants do not accumulate trehalose at significant levels they have actively transcribed genes encoding the corresponding biosynthetic enzymes.
resultsIn this study we show that trehalose biosynthesis ability is present in eubacteria, archaea, plants, fungi and animals. In bacteria there are five different biosynthetic routes, whereas in fungi, plants and animals there is only one. We present phylogenetic analyses of the trehalose-6-phosphate synthase (TPS) and trehalose-phosphatase (TPP) domains and show that there is a close evolutionary relationship between these domains in proteins from diverse organisms. In bacteria TPS and TPP genes are clustered, whereas in eukaryotes these domains are fused in a single protein.
conclusionWe have demonstrated that trehalose biosynthesis pathways are widely distributed in nature. Interestingly, several eubacterial species have multiple pathways, while eukaryotes have only the TPS/TPP pathway. Vertebrates lack trehalose biosynthetic capacity but can catabolise it. TPS and TPP domains have evolved mainly in parallel and it is likely that they have experienced several instances of gene duplication and lateral gene transfer.
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