ArticleParticle and fibre toxicology2006
Role of pyrite in formation of hydroxyl radicals in coal: possible implications for human health.
Article in Particle and fibre toxicology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Rhizosphere Reactive Oxygen Species: Detection Methods, Distribution Characteristics, Production Mechanisms, and Environmental Effects.Current issues in molecular biology · 2026Review
- Toxicity of respirable coal dust: An overview of origin, chemistry, mechanisms, and possible remedies.International journal of coal science & technology · 2026Review
- Machine Learning Demonstrates Dominance of Physical Characteristics over Particle Composition in Coal Dust Toxicity.Environmental science & technology · 2024Article
- The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals.Environmental geochemistry and health · 2023Review
- Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis.Respirology (Carlton, Vic.) · 2022Article
- An abiotic source of Archean hydrogen peroxide and oxygen that pre-dates oxygenic photosynthesis.Nature communications · 2021Article
- No association between pyrite content and lung cell responses to coal particles.Scientific reports · 2021Article
- Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications.Frontiers in chemistry · 2020Review
- Antimicrobial potential of two traditional herbometallic drugs against certain pathogenic microbial species.BMC complementary and alternative medicine · 2016Article
- The effect of pyrite on Escherichia coli in water: proof-of-concept for the elimination of waterborne bacteria by reactive minerals.Journal of water and health · 2015Article
- Metal-sulfide mineral ores, Fenton chemistry and disease--particle induced inflammatory stress response in lung cells.International journal of hygiene and environmental health · 2015Article
- Mineralogical variables that control the antibacterial effectiveness of a natural clay deposit.Environmental geochemistry and health · 2014Article
- Inflammatory stress response in A549 cells as a result of exposure to coal: evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis.Chemosphere · 2013Article
- Pyrite-driven reactive oxygen species formation in simulated lung fluid: implications for coal workers' pneumoconiosis.Environmental geochemistry and health · 2012Article
- Quantification of particle-induced inflammatory stress response: a novel approach for toxicity testing of earth materials.Geochemical transactions · 2012Article
- What makes a natural clay antibacterial?Environmental science & technology · 2011Article
- Estimation of the postmortem duration of mouse tissue by electron spin resonance spectroscopy.Journal of toxicology · 2011Article
- Adenine oxidation by pyrite-generated hydroxyl radicals.Geochemical transactions · 2010Article
- Evaluating the use of 3'-(p-Aminophenyl) fluorescein for determining the formation of highly reactive oxygen species in particle suspensions.Geochemical transactions · 2009Article
- Comparison of fluorescence-based techniques for the quantification of particle-induced hydroxyl radicals.Particle and fibre toxicology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe harmful effects from inhalation of coal dust are well-documented. The prevalence of lung disease varies by mining region and may, in part, be related to regional differences in the bioavailable iron content of the coal. Pyrite (FeS2), a common inorganic component in coal, has been shown to spontaneously form reactive oxygen species (ROS) (i.e., hydrogen peroxide and hydroxyl radicals) and degrade nucleic acids. This raises the question regarding the potential for similar reactivity from coal that contains pyrite. Experiments were performed to specifically evaluate the role of pyrite in coal dust reactivity. Coal samples containing various amounts of FeS2 were compared for differences in their generation of ROS and degradation of RNA.
resultsCoals that contain iron also show the presence of FeS2, generate ROS and degrade RNA. Coal samples that do not contain pyrite do not produce ROS nor degrade RNA. The concentration of generated ROS and degradation rate of RNA both increase with greater FeS2 content in the coals.
conclusionThe prevalence of coal workers' pneumoconiosis can be correlated to the amount of FeS2 in the coals. Considering the harmful effects of generation of ROS by inhaled particles, the results presented here show a possible mechanism whereby coal samples may contribute to CWP. This suggests that the toxicity of coal may be explained, in part, by the presence of FeS2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.