ArticleClinical and experimental immunology2007
The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Kawasaki disease: a meta-analysis.African health sciences · 2017Pooled it
- A genetic variant rs1801274 in FCGR2A as a potential risk marker for Kawasaki disease: a case-control study and meta-analysis.PloS one · 2014Pooled it
- FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome.Indian pediatrics · 2025Article
- Relationship between Kawasaki disease and alanine aminotransferase levels in pediatric patients.World journal of hepatology · 2025Article
- Article
- Epigenetics in Kawasaki Disease.Frontiers in pediatrics · 2021Review
- Perspective of Immunopathogenesis and Immunotherapies for Kawasaki Disease.Frontiers in pediatrics · 2021Review
- Immunogenetics of Kawasaki disease.Clinical reviews in allergy & immunology · 2020Review
- Kawasaki disease: pathophysiology and insights from mouse models.Nature reviews. Rheumatology · 2020Review
- Lower CMV and EBV Exposure in Children With Kawasaki Disease Suggests an Under-Challenged Immune System.Frontiers in pediatrics · 2020Article
- Extensive Ethnic Variation and Linkage Disequilibrium at theFrontiers in immunology · 2019Article
- The role of B cells and humoral immunity in Mycobacterium tuberculosis infection.Seminars in immunology · 2014Review
- FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response.Pharmacogenetics and genomics · 2013Article
- The role of infection in Kawasaki syndrome.The Journal of infection · 2013Review
- Genetics insights into the pathogenesis of Kawasaki disease.Circulation. Cardiovascular genetics · 2012Article
- Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.Circulation. Cardiovascular genetics · 2012Article
- A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses.BMC medicine · 2011Article
- Genetic polymorphisms in Kawasaki disease.Acta pharmacologica Sinica · 2011Review
- Article
- The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean children.Journal of clinical immunology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease is an acute febrile syndrome in infancy, characterized by vasculitis of medium-sized arteries. Without treatment the disease can lead to coronary artery lesions (CAL) in approximately 25% of the children. Therapy consists of intravenous immunoglobulins (IVIG), leading to a decrease of complications to 5-16%. Little is known about the working mechanisms of IVIG. In this study we evaluated the involvement of Fcgamma receptors (FcgammaRs) in Kawasaki disease by the determination of the frequency of known single nucleotide polymorphisms (SNPs) in the genes coding for the FcgammaRs and compared this with frequencies in a cohort of healthy controls. There was no difference in the distribution of the functionally relevant genotypes for FcgammaRIIa-131H/R, FcgammaRIIb-232I/T, FcgammaRIIIa-158 V/F and FcgammaRIIIb-NA1/NA2 between the patient group and the healthy controls. Furthermore, there were no polymorphisms linked to the disease severity as indicated by the absence or development of CAL during the disease. Altered transcription or expression of FcgammaR on specific cell types of the immune system may still play a role in susceptibility and treatment success, but at a level different from the functional SNPs in FcgammaR genes tested in this study.
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