ArticleClinical and experimental immunology2007
Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pooled it
- Pooled it
- Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis.iScience · 2024Article
- The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.Journal of neuroinflammation · 2024Review
- Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis.International journal of molecular sciences · 2022Review
- Toll-Like Receptor Signalling Pathways and the Pathogenesis of Retinal Diseases.Frontiers in ophthalmology · 2022Review
- Adhesion molecules: a way to understand lupus.Reumatologia · 2022Review
- Three Japanese cases of intraocular inflammation after intravitreal brolucizumab injections in one clinic.Japanese journal of ophthalmology · 2021Article
- Behçet's Syndrome as a Model of Thrombo-Inflammation: The Role of Neutrophils.Frontiers in immunology · 2019Review
- Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study.Cancer medicine · 2018Article
- Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients.Journal of neuroimmunology · 2018Article
- The role of Toll-like receptors in retinal ischemic diseases.International journal of ophthalmology · 2016Review
- T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins.International journal of cancer · 2014Article
- Suitability of endogenous reference genes for gene expression studies with human intraocular endothelial cells.BMC research notes · 2013Article
- Role of the retinal vascular endothelial cell in ocular disease.Progress in retinal and eye research · 2013Review
- Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.Annals of the New York Academy of Sciences · 2010Review
- Immune regulation in the retina.Immunologic research · 2010Review
- Regulatory role of TLR ligands on the activation of autoreactive T cells by retinal astrocytes.Investigative ophthalmology & visual science · 2009Article
- Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.Clinical and experimental immunology · 2009Review
- Retinal Vasculitis Associated With Dermatomyositis Treated With Intravenous Steroids.Journal of vitreoretinal diseasesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Retinal vasculitis is a major component of ocular inflammation that plays a role in retinal tissue damage in patients with idiopathic uveitis and Behçet's disease. Here we show that type 1 interferons (IFN alpha/beta) were not detected in sera from normal individuals but were identified in up to 46% of the sera from retinal vasculitis patients. The predominant form of IFN observed was IFN-beta, which was detected in 39% of Behçet's disease patients and 47% of idiopathic uveitis patients. Seven patients whose sera contained IFN-beta were monitored prospectively. IFN-beta was shown to be present for 6-12 months in all seven of the sera samples tested. Furthermore, the adhesion molecule profile identified in this study was strikingly different when Behçet's and uveitis patient sera were compared to sera from normal controls. Sera from Behçet's disease patients contained significantly elevated levels of the soluble adhesion molecules, sE-selectin and s-intracellular adhesion molecule-1 (sICAM-1), whereas sera from patients with idiopathic uveitis contained significantly increased sE-selectin. In vitro studies evaluating the cell source of these cytokines revealed that polyriboinosinic polyribocytidylic acid (poly I:C) activated retinal vascular endothelial cells produce sE-selectin, sICAM-1 and IFN-beta. Production of these molecules was inhibited by pretreatment with anti-Toll-like receptor 3 (TLR-3) antibody. In conclusion, IFN-beta, sE-selectin and sICAM-1 are elevated in patients with retinal vasculitis and are induced in retinal vascular endothelial cells in vitro by activating the innate immune system through TLR-3. Further analysis of innate immune signalling may prove to be a novel target for future studies on pathogenic mechanisms and therapeutic approaches in retinal vasculitis.
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