Trial reportClinical and experimental immunology2007
Nicotine exposure alters in vivo human responses to endotoxin.
Trial report in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option?Internal and emergency medicine · 2020Pooled it
- Influence of acute epinephrine infusion on endotoxin-induced parameters of heart rate variability: a randomized controlled trial.Annals of surgery · 2009Trial
- New intervention strategy for postoperative fatigue syndrome in elderly patients with colorectal cancer: a clinical hypothesis study based on vagus nerve stimulation.Frontiers in medicine · 2025Article
- Review
- Medicinal nicotine in COVID-19 acute respiratory distress syndrome, the new corticosteroid.World journal of critical care medicine · 2022Review
- The Prevalence of Diabetes, Prediabetes and Associated Risk Factors in Hangzhou, Zhejiang Province: A Community-Based Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- [Pathogenesis of hidradenitis suppurativa/acne inversa].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Review
- Association of smoking history with severe and critical outcomes in COVID-19 patients: A systemic review and meta-analysis.European journal of integrative medicine · 2021Article
- Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes.ERJ open research · 2021Article
- Nicotinic Acetylcholine Receptor Involvement in Inflammatory Bowel Disease and Interactions with Gut Microbiota.International journal of environmental research and public health · 2021Review
- Smoking Enigma in Coronavirus Disease 2019: A Tug of War between Predisposition and Possible Way Out.Tobacco use insights · 2021Article
- Retrospective study on rib fractures: smoking and alcohol matter for mortality and complications.Trauma surgery & acute care open · 2021Article
- Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Smoking and COVID-19: Adding Fuel to the Flame.International journal of molecular sciences · 2020Review
- Smoking is associated with an improved short-term outcome in patients with rib fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Hidradenitis suppurativa.Nature reviews. Disease primers · 2020Review
- GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors.PloS one · 2019Article
- The Intersection of Sex Differences, Tobacco Use, and Inflammation: Implications for Psychiatric Disorders.Current psychiatry reports · 2018Review
- Cholinergic modulation of the immune system presents new approaches for treating inflammation.Pharmacology & therapeutics · 2017Review
- Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The alpha 7 nicotinic receptor is reportedly a key element in the cholinergic anti-inflammatory pathway. Because a prototypical ligand for this receptor is nicotine, we studied the in vivo human response to bacterial endotoxin or lipopolysaccharide (LPS) in the context of nicotine or placebo pretreatment. Twelve adult male normal subjects were studied prospectively. Six received overnight transcutaneous nicotine administration by application of a standard patch (7 mg). Six hours later, all subjects were given an intravenous dose of endotoxin (2 ng/kg) and were evaluated for an additional 24 h for circulating levels of inflammatory biomarkers, vital signs and symptoms. The nicotine subjects had elevated blood levels of the nicotine metabolite, continine, prior to and throughout the 24-h post-endotoxin exposure phase. Subjects receiving nicotine exhibited a significantly lower temperature response as well as attenuated cardiovascular responses for 2.5-6 h after LPS exposure. In addition, increased circulating interkeukin (IL)-10 and cortisol levels were also noted in nicotine subjects. These data indicate an alteration in LPS-induced systemic inflammatory responses in normal subjects exposed to transcutaneous nicotine. In this model of abbreviated inflammation, nicotine exposure attenuates the febrile response to LPS and promotes a more prominent anti-inflammatory phenotype.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.