Evidence map›Paper›PMID 17177183›Full record

ArticleAmerican journal of physical anthropology2007

Argentine population genetic structure: large variance in Amerindian contribution.

Michael F Seldin, Chao Tian, Russell Shigeta, Hugo R Scherbarth, Gabriel Silva, John W Belmont, Rick Kittles, Susana Gamron, Alberto Allevi, Simon A Palatnik and 11 more

Abstract read
In one paragraph

Article in American journal of physical anthropology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 89 citations in OpenAlex.

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  17. Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2013
    Article
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  20. Five years of GWAS discovery.American journal of human genetics · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 14 institutions in 3 countries.

Michael F SeldinRowe Program in Human Genetics, Department of Biological Chemistry, University of California Davis, Davis, CA 95616, USA. mfseldin@ucdavis.edu
Chao Tian
Russell Shigeta
Hugo R Scherbarth
Gabriel Silva
John W Belmont
Rick Kittles
Susana Gamron
Alberto Allevi
Simon A Palatnik
Alejandro Alvarellos
Sergio Paira
Cesar Caprarulo
Carolina Guillerón
Luis J Catoggio
Cristina Prigione
Guillermo A Berbotto
Mercedes A García
Carlos E Perandones
Bernardo A Pons-Estel
Marta E Alarcon-Riquelme
University of California, Davis · USHospital Provincial de Rosario · ARBaylor College of Medicine · USCentro Científico Tecnólogico - Rosario · ARCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · AREl Hospital General de Agudos Carlos G. Durand · ARHospital Fernández · ARHospital Italiano de Buenos Aires · ARHospital Privado · ARNational University of General San Martín · ARThe Ohio State University · USUniversidad Nacional de Córdoba · ARUniversity of Buenos Aires · ARUppsala University · SE

Funding

MA Admixture Mapping Development &Application to NIDDMR01DK071185 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI SELDIN, MICHAEL F. · 2005 to 2008
$1.9M
NIDDK NIH HHS R01 DK071185
6 · The paper itself

Abstract

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.

Indexed as

Asian PeopleBayes TheoremBlack PeopleGene FrequencyGenetic MarkersGenetics, PopulationGenetic VariationHumansIndians, South AmericanMexican AmericansWhite PeopleGenetic Markers

Identifiers

PMID17177183
PMCPMC3142769
OpenAlexW2140778122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.