ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2006
Mechanism of gastric bypass-induced body weight loss: one-year follow-up after micro-gastric bypass in rats.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats.Obesity surgery · 2017Article
- Roux-en-Y gastric bypass augments the feeding responses evoked by gastrin-releasing peptides.The Journal of surgical research · 2016Article
- Article
- The Use of Rat and Mouse Models in Bariatric Surgery Experiments.Frontiers in nutrition · 2016Review
- Bone metabolism after bariatric surgery.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Review
- Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats.Nutrition & diabetes · 2014Article
- Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models.PloS one · 2013Article
- Experimental metabolic surgery: justification and technical aspects.Obesity surgery · 2011Article
- Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.Stem cells and development · 2011Article
- Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.Obesity surgery · 2010Review
- Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass.Obesity surgery · 2010Article
- Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young rats.Obesity surgery · 2009Article
- Is a pouch compulsory in Roux-en-Y gastric bypass after failed adjustable gastric banding?Obesity surgery · 2008Article
- Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: a feasibility study.Surgical endoscopy · 2008Article
- Gastric bypass surgery causes body weight loss without reducing food intake in rats.Obesity surgery · 2008Article
- Bariatric surgery: the past, present, and future.Obesity surgery · 2008Article
- Laparoscopic gastric bypass with subtotal gastrectomy for a super-obese patient with Biermer anemia.Obesity surgery · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bariatric surgery (Roux-en-Y or mini-gastric bypass) is designed to limit food intake by creating a small gastric pouch and to reduce nutrient absorption by bypassing the long limb of the intestine. We report 1-year follow-up results after micro-gastric bypass in rats. Micro-gastric bypass was performed by anastomosis of the esophagus and the proximal jejunum. Body weight, body composition, bone mineral density, food intake, and serum levels of ghrelin and obestatin were measured. Growing rats had a 40% weight reduction 2 months after micro-gastric bypass surgery compared to 20% after gastrectomy and 30% after stomach bypass (anastomosis of the esophagus and duodenal bulb). Six months after micro-gastric bypass surgery, the rats stopped growing compared to controls that gained continuously due to expansion of the fat compartment. Adult rats (600 g) lost 30% of their body weight 5 months after the micro-gastric bypass, while food intake was not reduced. Serum levels of obestatin (but not ghrelin) were reduced in rats with micro-gastric bypass. The results suggest that micro-gastric bypass efficiently reduced body weight, particularly fat mass; loss of the weight after micro-gastric bypass was not due to reduced food intake; and lean tissue and bone development were impaired in growing subjects after gastric bypass.
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