ArticleHearing research2007
Genetic dependence of cochlear cells and structures injured by noise.
Article in Hearing research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Characterization of mouse melanocytes reveals ultrastructural and immunological insights into the inner ear function.Communications biology · 2026Article
- A critical evaluation of "leakage" at the cochlear blood-stria-barrier and its functional significance.Frontiers in molecular neuroscience · 2024Review
- Article
- Untangling the genomics of noise-induced hearing loss and tinnitus: Contributions of Mus musculus and Homo sapiens.The Journal of the Acoustical Society of America · 2019Review
- Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'.Purinergic signalling · 2019Article
- The Stress Response in the Non-sensory Cells of the Cochlea Under Pathological Conditions-Possible Role in Mediating Noise Vulnerability.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte.Scientific reports · 2018Article
- The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.Hearing research · 2018Article
- Clinical evaluation and molecular screening of a large consecutive series of albino patients.Journal of human genetics · 2017Article
- Article
- Application of Mouse Models to Research in Hearing and Balance.Journal of the Association for Research in Otolaryngology : JARO · 2016Review
- The effects of aging and sex on detection of ultrasonic vocalizations by adult CBA/CaJ mice (Mus musculus).Hearing research · 2016Article
- Pathophysiology of the cochlear intrastrial fluid-blood barrier (review).Hearing research · 2016Review
- QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Swept-sine noise-induced damage as a hearing loss model for preclinical assays.Frontiers in aging neuroscience · 2015Article
- Transforming growth factor β1 inhibition protects from noise-induced hearing loss.Frontiers in aging neuroscience · 2015Article
- Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.Frontiers in cellular neuroscience · 2015Article
- Differences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and mice.PloS one · 2014Article
- The efficiency of design-based stereology in estimating spiral ganglion populations in mice.Hearing research · 2013Article
- Physiological, anatomical, and behavioral changes after acoustic trauma in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The acute and permanent effects of a single damaging noise exposure were compared in CBA/J, C57BL/6 (B6), and closely related strains of mice. Two hours of broadband noise (4-45 kHz) at 110 dB SPL led to temporary reduction in the endocochlear potential (EP) of CBA/J and CBA/CaJ (CBA) mice and acute cellular changes in cochlear stria vascularis and spiral ligament. For the same exposure, B6 mice showed no EP reduction and little of the pathology seen in CBA. Eight weeks after exposure, all mice showed a normal EP, but only CBA mice showed injury and cell loss in cochlear lateral wall, despite the fact that B6 sustained larger permanent threshold shifts. Examination of noise injury in B6 congenics carrying alternate alleles of genes encoding otocadherin (Cdh23), agouti protein, and tyrosinase (albinism) indicated that none of these loci can account for the strain differences observed. Examination of CBA x B6 F1 mice and N2 backcross mice to B6 further indicated that susceptibility to noise-related EP reduction and associated cell pathology are inherited in an autosomal dominant manner, and are established by one or a few large effect quantitative trait loci. Findings support a common genetic basis for an entire constellation of noise-related cochlear pathologies in cochlear lateral wall and spiral limbus. Even within species, cellular targets of acute and permanent cochlear noise injury may vary with genetic makeup.
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Registered trials
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