ArticleCell2006
Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference.
Article in Cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
146 citing papers in PubMed, 276 citations in OpenAlex.
- Transcriptional interference revisited.Nature genetics · 2026Review
- Transcriptional interference gates monogenic odorant receptor expression in ants.Current biology : CB · 2025Article
- A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family.Genes & development · 2025Article
- Transcriptional Interference Gates Monogenic Odorant Receptor Expression in Ants.bioRxiv : the preprint server for biology · 2025Article
- Decoding subcellular RNA localization one molecule at a time.Genome biology · 2025Review
- A Synergistic, Cultivator Model of De Novo Gene Origination.Genome biology and evolution · 2024Article
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- Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.Trends in genetics : TIG · 2023Review
- The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.Cell reports · 2023Article
- Dynamic interplay between non-coding enhancer transcription and gene activity in development.Nature communications · 2023Article
- The Functional Meaning of 5'UTR in Protein-Coding Genes.International journal of molecular sciences · 2023Review
- Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development.Molecular cell · 2022Article
- Plant and animal small RNA communications between cells and organisms.Nature reviews. Molecular cell biology · 2022Review
- Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.PLoS genetics · 2021Article
- Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin.International journal of molecular sciences · 2021Review
- Long Non-Coding RNAs in Insects.Animals : an open access journal from MDPI · 2021Review
- An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference.PLoS genetics · 2021Article
- Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021Article
- AnnoLnc: A One-Stop Portal to Systematically Annotate Novel Human Long Noncoding RNAs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- dsRNA Uptake in Plant Pests and Pathogens: Insights into RNAi-Based Insect and Fungal Control Technology.Plants (Basel, Switzerland) · 2020Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
Much of the genome is transcribed into long noncoding RNAs (ncRNAs). Previous data suggested that bithoraxoid (bxd) ncRNAs of the Drosophila bithorax complex (BX-C) prevent silencing of Ultrabithorax (Ubx) and recruit activating proteins of the trithorax group (trxG) to their maintenance elements (MEs). We found that, surprisingly, Ubx and several bxd ncRNAs are expressed in nonoverlapping patterns in both embryos and imaginal discs, suggesting that transcription of these ncRNAs is associated with repression, not activation, of Ubx. Our data rule out siRNA or miRNA-based mechanisms for repression by bxd ncRNAs. Rather, ncRNA transcription itself, acting in cis, represses Ubx. The Trithorax complex TAC1 binds the Ubx coding region in nuclei expressing Ubx, and the bxd region in nuclei not expressing Ubx. We propose that TAC1 promotes the mosaic pattern of Ubx expression by facilitating transcriptional elongation of bxd ncRNAs, which represses Ubx transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.