ArticleThe Journal of cell biology1991
A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed.
- Targeting SRPK3 Attenuates Cardiac Hypertrophy and Heart Failure by Improving Mitochondrial Bioenergetics through mRNA Splicing and Decay.Research (Washington, D.C.) · 2026Article
- Regulation of theRNA (New York, N.Y.) · 2024Article
- Oncogenic SRSF3 in health and diseases.International journal of biological sciences · 2023Review
- Insights into sweet potato SR proteins: from evolution to species-specific expression and alternative splicing.Planta · 2022Article
- A Comprehensive Identification and Function Analysis of Serine/Arginine-Rich (SR) Proteins in Cotton (International journal of molecular sciences · 2022Article
- Targeting Splicing Factor SRSF6 for Cancer Therapy.Frontiers in cell and developmental biology · 2021Review
- TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments.International journal of molecular sciences · 2020Article
- Trpc1 as the Missing Link Between the Bmp and CaScientific reports · 2019Article
- Coordinated Regulation of Pre-mRNA Splicing by the SFPS-RRC1 Complex to Promote Photomorphogenesis.The Plant cell · 2019Article
- Review
- Cross-β Polymerization of Low Complexity Sequence Domains.Cold Spring Harbor perspectives in biology · 2017Review
- Article
- Involvement of the N-Terminal Deubiquitinating Protease Domain of Human Cytomegalovirus UL48 Tegument Protein in Autoubiquitination, Virion Stability, and Virus Entry.Journal of virology · 2016Article
- Gbp2 interacts with THO/TREX through a novel type of RRM domain.Nucleic acids research · 2016Article
- Requirement of the N-terminal residues of human cytomegalovirus UL112-113 proteins for viral growth and oriLyt-dependent DNA replication.Journal of microbiology (Seoul, Korea) · 2015Article
- SR protein kinases promote splicing of nonconsensus introns.Nature structural & molecular biology · 2015Article
- Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.PLoS pathogens · 2015Article
- The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.Annual review of biochemistry · 2015Review
- Male-specific phosphorylated SR proteins in adult flies of the Mediterranean fruitfly Ceratitis capitata.BMC genetics · 2014Article
- Review
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
An antibody was identified previously that recognizes sites of polymerase II transcription on lampbrush chromosomes, puffs on polytene chromosomes, and many small granules in the nucleoplasm of all cells tested. This antibody binds a conserved family of phosphorylated polypeptides in vertebrate and invertebrate cells. We developed a method for purifying these proteins that involves differential solubility in MgCl2. We isolated a Drosophila cDNA encoding one of the proteins using information obtained from microsequencing. In vivo expression studies show that this protein is concentrated on sites of polymerase II transcription and that it is highly phosphorylated. The protein shares a high degree of homology with proteins involved in alternative splicing of pre-mRNA suggesting the possibility that this protein plays a role in pre-mRNA splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.