ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2006
Multicenter intercomparison assessment of consistency of left ventricular function from a gated cardiac SPECT phantom.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A novel dynamic cardiac phantom for comparing blood pool and myocardial perfusion tracers: initial evaluation with CZT-ERNA and PET-MPI.EJNMMI physics · 2026Article
- Evaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data.EJNMMI physics · 2015Article
- Cell therapy in myocardial infarction: emphasis on the role of MRI.European radiology · 2008Review
- The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in women.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundA multicenter intercomparison assessment was made of the variation in left ventricular (LV) volumes and ejection fractions (EFs) obtained from gated myocardial perfusion single photon emission computed tomography (SPECT) of the 3-dimensional AGATE (Amsterdam gated) cardiac phantom. METHODS AND
resultsThe phantom was configured to produce 3 different standard end-systolic volume and end-diastolic volume combinations (50 mL and 120 mL, 90 mL and 160 mL, and 120 mL and 190 mL) with corresponding EF (58%, 44%, and 37%). Quantitative gated myocardial perfusion SPECT was performed with 39 SPECT systems in 35 departments. In the multicenter study, for all 3 filling conditions, a wide range of results was obtained. The EF was overestimated (by 1% to 15%), and both the end-systolic volume and end-diastolic volume were underestimated (by 1 to 65 mL). The extent of overestimation of EF was related to the extent of underestimation of the volumes and was independent of filling condition. The trend in error per center was comparable for all 3 filling conditions. Acquisition time per projection was the only independent predictor of the difference between measured and expected EF (P = .0001).
conclusionsCare should be taken before extrapolation of published and accepted cutoff values for LV EF and volumes in clinical decision making. Results should be validated in each center and monitored for accuracy and consistency over time.
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