Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2006
Changing patterns of abnormal vascular wall F-18 fluorodeoxyglucose uptake on follow-up PET/CT studies.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Effect of moderate-intensity statin therapy on plaque inflammation in patients with acute coronary syndrome: A prospective interventional study evaluated by 18F-FDG PET/CT of the carotid artery.Cardiology journal · 2020Article
- Optimizing FDG-PET/CT imaging of inflammation in atherosclerosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Positron emission tomography of the vulnerable atherosclerotic plaque in man--a contemporary review.Clinical physiology and functional imaging · 2014Review
- PET imaging of inflammation in atherosclerosis.Nature reviews. Cardiology · 2014Review
- Inflammation, Atherosclerosis, and Coronary Artery Disease: PET/CT for the Evaluation of Atherosclerosis and Inflammation.Clinical Medicine Insights. Cardiology · 2014Review
- Complementarity between (18)F-FDG PET/CT and Ultrasonography or Angiography in Carotid Plaque Characterization.Journal of clinical neurology (Seoul, Korea) · 2013Article
- Imaging atherosclerosis with hybrid [18F]fluorodeoxyglucose positron emission tomography/computed tomography imaging: what Leonardo da Vinci could not see.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- Assessing global cardiovascular molecular calcification with 18F-fluoride PET/CT: will this become a clinical reality and a challenge to CT calcification scoring?European journal of nuclear medicine and molecular imaging · 2012Article
- High-resolution imaging of human atherosclerotic carotid plaques with micro 18F-FDG PET scanning exploring plaque vulnerability.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Molecular imaging of atherosclerosis in translational medicine.European journal of nuclear medicine and molecular imaging · 2011Review
- New Intraspinal cause of physiological FDG uptake.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India · 2010Article
- Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification.European journal of nuclear medicine and molecular imaging · 2009Article
- Atherosclerotic plaque imaging by PET/CT; can inactive, active and mixed plaques be discerned?The international journal of cardiovascular imaging · 2009Article
- Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.European journal of nuclear medicine and molecular imaging · 2009Review
- Quantitative plaque characterization with coronary CT angiography (CTA): current challenges and future application in atherosclerosis trials and clinical risk assessment.The international journal of cardiovascular imaging · 2008Article
- Fluorodeoxyglucose and calcium uptake in the vascular wall: clinically relevant or sugar-coated pill?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Article
- Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques.Korean journal of radiologyReview
- Vascular FDG uptake: further steps toward clinical acceptance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · on this mapArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluorine 18 fluorodeoxyglucose (FDG) uptake may be increased in atherosclerotic plaques in asymptomatic patients. Repeat positron emission tomography (PET)/computed tomography (CT) studies were assessed for changes in patterns of FDG uptake and CT calcifications. METHODS AND
resultsFifty consecutive cancer patients (mean age, 68 +/- 8 years) had repeat PET/CT studies 8 to 26 months apart. PET, CT, and PET/CT images were retrospectively evaluated for vascular wall abnormalities and for interval changes in the thoracic and abdominal aortas, as well as in carotid and iliac arteries, classified as PET+/CT+, PET+/CT-, and PET-/CT+. There were 485 abnormal sites in the first study and 495 in the second. CT calcifications were found in 46 patients (92%) in the first study and in 47 (94%) in the second. Vascular wall FDG uptake was found in both studies in 37 patients (74%). The pattern changed in 57 of 119 PET+ sites (48%) in the second study compared with 15 of 366 PET- sites (4%) (P < .0001). In the second study new PET+ sites were observed in 36 of 111 sites (32%) versus new PET-/CT+ sites in 19 of 384 sites (5%) (P < .0001).
conclusionsChanges in vascular FDG activity and CT calcifications can be assessed by repeat PET/CT. FDG-avid foci may represent a dynamic process, transient inflammation, whereas CT calcifications may indicate stable atherosclerosis. These preliminary results support the need for further research.
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