ArticleThe Journal of cell biology1991
Paxillin is a major phosphotyrosine-containing protein during embryonic development.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 118 citations in OpenAlex.
- Paxillin mediates ARP2-dependent actin assembly for spindle migration in mammalian oocyte meiosis.Biology direct · 2026Article
- Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications.Advanced drug delivery reviews · 2024Review
- Paxillin Is Required for Proper Spinal Motor Axon Growth into the Limb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Paxillin: a crossroad in pathological cell migration.Journal of hematology & oncology · 2017Review
- The Lhx9-integrin pathway is essential for positioning of the proepicardial organ.Development (Cambridge, England) · 2016Article
- Extracellular matrix-mediated cellular communication in the heart.Journal of molecular and cellular cardiology · 2016Review
- Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.The Journal of biological chemistry · 2014Article
- Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells.The Journal of biological chemistry · 2012Article
- The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.Molecular biology of the cell · 2011Article
- Paxillin comes of age.Journal of cell science · 2008Review
- Estradiol and the developing brain.Physiological reviews · 2008Review
- Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.The Journal of cell biology · 2005Article
- Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis.Molecular biology of the cell · 2003Article
- The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.Molecular and cellular biology · 2002Article
- A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila.EMBO reports · 2001Article
- Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts.Oncogene · 1999Article
- Protein phosphorylation during coconut zygotic embryo developmentPlant physiology · 1998Article
- Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Phosphotyrosine-containing proteins were immunoprecipitated from embryonic chicken tissue extracts using anti-phosphotyrosine antibody coupled to agarose beads. Major phosphotyrosine-containing proteins of 110, 70, and 50 kD were observed following blotting with anti-phosphotyrosine antibody. The 70-kD band was selectively removed from the samples by precipitation with antibodies to the focal adhesion protein paxillin, therefore identifying paxillin as one of the major tyrosine kinase substrates during chick embryonic organogenesis. The tyrosine phosphorylation of paxillin is regulated developmentally: during embryogenesis, a marked decrease in its phosphotyrosine content was observed, although the total level of paxillin remained essentially constant. Approximately 20% of the paxillin was phosphorylated on tyrosine in the early embryo. In contrast, tyrosine phosphorylation of paxillin was undetectable in the adult. A similar profile of phosphotyrosine-containing proteins was identified in rat embryos. Paxillin was also found to be a major phosphotyrosine-containing protein in the rat embryo. These data suggest that the regulated phosphorylation of tyrosine residues on paxillin may perform a critical role in controlling cell and tissue cytoarchitecture rearrangement during vertebrate development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.