ReviewNeuroscience2007
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
Review in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Toxic effect of alpha cypermethrin, an environmental pollutant, on myocardial tissue in male wistar rats.Environmental science and pollution research international · 2020Article
- Article
- Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase.Journal of structural biology · 2017Article
- Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals.Acta crystallographica. Section F, Structural biology communications · 2017Article
- Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.Journal of bacteriology · 2015Article
- The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.Free radical biology & medicine · 2014Article
- Developing advanced X-ray scattering methods combined with crystallography and computation.Methods (San Diego, Calif.) · 2013Review
- Amyotrophic lateral sclerosis: update and new developments.Degenerative neurological and neuromuscular disease · 2012Article
- A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.The American journal of pathology · 2011Article
- Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.Acta neuropathologica · 2011Review
- All stressed out without ATM kinase.Science signaling · 2011Article
- Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.The Journal of biological chemistry · 2010Article
- The structural biochemistry of the superoxide dismutases.Biochimica et biophysica acta · 2010Review
- Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.Biochemistry · 2009Article
- Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.Journal of molecular biology · 2009Article
- The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.Biochemistry · 2008Article
- Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains.DNA repair · 2008Article
- Mitochondrial medicine: pharmacological targeting of mitochondria in disease.British journal of pharmacology · 2007Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
This review is focused on proteins with key roles in pathways controlling either reactive oxygen species or DNA damage responses, both of which are essential for preserving the nervous system. An imbalance of reactive oxygen species or inappropriate DNA damage response likely causes mutational or cytotoxic outcomes, which may lead to cancer and/or aging phenotypes. Moreover, individuals with hereditary disorders in proteins of these cellular pathways have significant neurological abnormalities. Mutations in a superoxide dismutase, which removes oxygen free radicals, may cause the neurodegenerative disease amyotrophic lateral sclerosis. Additionally, DNA repair disorders that affect the brain to various extents include ataxia-telangiectasia-like disorder, Cockayne syndrome or Werner syndrome. Here, we highlight recent advances gained through structural biochemistry studies on enzymes linked to these disorders and other related enzymes acting within the same cellular pathways. We describe the current understanding of how these vital proteins coordinate chemical steps and integrate cellular signaling and response events. Significantly, these structural studies may provide a set of master keys to developing a unified understanding of the survival mechanisms utilized after insults by reactive oxygen species and genotoxic agents, and also provide a basis for developing an informed intervention in brain tumor and neurodegenerative disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.