ArticleCell cycle (Georgetown, Tex.)2006
p21(Waf1/Cip1) deficiency stimulates centriole overduplication.
Article in Cell cycle (Georgetown, Tex.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence.The Prostate · 2022Article
- Function of p21 (Cip1/Waf1/Cancers · 2019Article
- European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects.Frontiers in oncology · 2019Article
- Clinically Applicable Inhibitors Impacting Genome Stability.Molecules (Basel, Switzerland) · 2018Review
- CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.Scientific reports · 2017Article
- Review
- GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis.Cell death & disease · 2014Article
- CEP proteins: the knights of centrosome dynasty.Protoplasma · 2013Review
- 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis.Journal of radiation research · 2012Article
- Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.PloS one · 2012Article
- The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Cell division · 2011Article
- The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.Oncogene · 2010Article
- Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.Molecular and cellular biology · 2010Article
- H2AX is required for cell cycle arrest via the p53/p21 pathway.Molecular and cellular biology · 2009Article
- Classification of chromosome segregation errors in cancer.Chromosoma · 2008Review
- When 2+2=5: the origins and fates of aneuploid and tetraploid cells.Biochimica et biophysica acta · 2008Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inactivation of the cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1) (CDKN1; hereafter p21) has previously been implicated in the induction of numerical centrosome alterations. It is unclear, however, whether p21 deficiency deregulates the centrosome duplication cycle itself or causes an accumulation of centrosomes due to cell division failure and/or polyploidization. Using a novel marker for maternal centrioles, Cep170, we show here that knock-down of p21 protein expression in murine myeloblasts can stimulate excessive centriole numbers in the presence of only one mature centriole. These results indicate that p21 deficiency can trigger a bona fide overduplication of centrioles and that aberrant centrosome numbers cannot solely be explained by polyploidization as suggested by previous studies. Our findings underscore that impaired p21 expression may function as a driving force for chromosomal instability and highlight the importance of markers for maternal centrioles such as Cep170 to elucidate the pathogenesis of numerical centriole aberrations in tumor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.