ReviewMolecular biotechnology2006
Chlamydomonas reinhardtii: a protein expression system for pharmaceutical and biotechnological proteins.
Review in Molecular biotechnology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Amyloid β-peptide multimer expressed in green algae efficiently inhibits bacteria growth by disrupting cell membrane permeability.Scientific reports · 2025Article
- The First Introduction of an Exogenous 5' Untranslated Region for Control of Plastid Transgene Expression in Chlamydomonas reinhardtii.Molecular biotechnology · 2025Article
- CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green MicroalgaPlants (Basel, Switzerland) · 2024Article
- A potential paradigm in CRISPR/Cas systems delivery: at the crossroad of microalgal gene editing and algal-mediated nanoparticles.Journal of nanobiotechnology · 2023Review
- Review
- Expression of fatty acid related gene promotes astaxanthin heterologous production inFrontiers in nutrition · 2023Article
- Recombinant Protein Production and Purification of Insoluble Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Synergistic effects of contaminants in Lombardy waters.Scientific reports · 2021Article
- CRISPR-Cas9 System for Genome Engineering of Photosynthetic Microalgae.Molecular biotechnology · 2019Review
- Engineering Chlamydomonas reinhardtii for Expression of Functionally Active Human Interferon-α.Molecular biotechnology · 2019Article
- Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii.International archives of allergy and immunology · 2017Article
- The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals.International journal of molecular sciences · 2016Review
- An efficient protocol for the Agrobacterium-mediated genetic transformation of microalga Chlamydomonas reinhardtii.Molecular biotechnology · 2014Article
- Potential for green microalgae to produce hydrogen, pharmaceuticals and other high value products in a combined process.Critical reviews in biotechnology · 2013Review
- An engineered diatom acting like a plasma cell secreting human IgG antibodies with high efficiency.Microbial cell factories · 2012Article
- Sequence analysis and potentials of the native RbcS promoter in the development of an alternative eukaryotic expression system using green Microalga Ankistrodesmus convolutus.International journal of molecular sciences · 2012Article
- Micro-algae come of age as a platform for recombinant protein production.Biotechnology letters · 2010Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant proteins have become more and more important for the pharmaceutical and chemical industry. Although various systems for protein expression have been developed, there is an increasing demand for inexpensive methods of large-scale production. Eukaryotic algae could serve as a novel option for the manufacturing of recombinant proteins, as they can be cultivated in a cheap and easy manner and grown to high cell densities. Being a model organism, the unicellular green alga Chlamydomonas reinhardtii has been studied intensively over the last decades and offers now a complete toolset for genetic manipulation. Recently, the successful expression of several proteins with pharmaceutical relevance has been reported from the nuclear and the chloroplastic genome of this alga, demonstrating its ability for biotechnological applications.
Indexed as
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17172667What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.