ReviewImmunologic research2006
Promise and pitfalls in animal-based asthma research: building a better mousetrap.
Review in Immunologic research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- A current review on animal models of anti-asthmatic drugs screening.Frontiers in pharmacology · 2025Review
- Long-Acting Beta Agonists Enhance Allergic Airway Disease.PloS one · 2015Article
- Airway fibrinogenolysis and the initiation of allergic inflammation.Annals of the American Thoracic Society · 2014Review
- Animal models of allergic airways disease: where are we and where to next?Journal of cellular biochemistry · 2014Review
- Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation?Journal of allergy & therapy · 2012Article
- Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways.Frontiers in immunology · 2012Article
- Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.The Journal of allergy and clinical immunology · 2011Article
- Asthma treatment through the beta receptor: lessons from animal models.Frontiers in bioscience (Elite edition) · 2011Article
- Respiratory tract allergic disease and atopy: experimental evidence for a fungal infectious etiology.Medical mycology · 2011Review
- Seeking common pathophysiology in asthma, atopy and sinusitis.Trends in immunology · 2011Article
- Animal models of asthma.American journal of physiology. Lung cellular and molecular physiology · 2009Review
- Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha).Immunologic research · 2009Review
- Toward a comprehensive understanding of allergic lung disease.Transactions of the American Clinical and Climatological Association · 2009Review
- A new mechanism for inhalational priming: IL-4 bypasses innate immune signals.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Usefulness and optimization of mouse models of allergic airway disease.The Journal of allergy and clinical immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Asthma is one of the leading chronic diseases in the world today. An essential component of the asthma research endeavor is the animal-based experimental disease system, which provides knowledge that is not attainable through study of patients alone. Animal research is especially valuable for elucidating pathophysiology, drug testing, and as an adjunct for interpreting the results of human clinical trials. However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research. We consider here the considerable promise and important limitations of animal-based systems and their prospects for the future study asthma.
Indexed as
Identifiers
17172652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.