Evidence map›Paper›PMID 17172551›Full record

Trial reportNeurorehabilitation and neural repair

The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial.

B Dobkin, H Barbeau, D Deforge, J Ditunno, R Elashoff, D Apple, M Basso, A Behrman, S Harkema, M Saulino and 2 more

3 registry-linked trialsOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 80 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03458169 nacompletednot on this map

Usability of a New Overground Body Weight Support Rehabilitation Robot LEAP: A Monocentric Consideration-of-concept Trial

TypeinterventionalSponsorClinique Romande de ReadaptationRan2018 to 2018Enrolled43ConditionsSpinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple SclerosisArmsTherapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
NCT05345301 nacompletednot on this map

Electroencephalographic Correlates of Glove-stretch Therapy Post-stroke

TypeinterventionalSponsorShirley Ryan AbilityLabRan2022 to 2022Enrolled10ConditionsStrokeArmsEvent related desynchronization measurement
NCT06137456 nacompletednot on this map

First Report of a New Exoskeleton in Incomplete Spinal Cord Injury: FreeGait®

TypeinterventionalSponsorAnkara City Hospital BilkentRan2022 to 2023Enrolled14ConditionsSpinal Cord Injuries, Walking, DifficultyArmsExoskeletal robotic therapy for walking., Conventional exercise therapy
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 197 citations in OpenAlex.

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  8. Exploiting telerobotics for sensorimotor rehabilitation: a locomotor embodiment.Journal of neuroengineering and rehabilitation · 2021
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  15. User-driven control increases cortical activity during treadmill walking: an EEG study.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2014
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  17. A user-driven treadmill control scheme for simulating overground locomotion.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2012
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

B DobkinDepartment of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA. bdobkin@mednet.ucla.edu
H Barbeau
D Deforge
J Ditunno
R Elashoff
D Apple
M Basso
A Behrman
S Harkema
M Saulino
M Scott
Spinal Cord Injury Locomotor Trial Group
Magee Rehabilitation Hospital · USUniversity of California, Los Angeles · USMcGill University · CAOttawa Hospital · CARancho Los Amigos National Rehabilitation Center · USShepherd Center · USThe Ohio State University · USUniversity of Florida · USUniversity of Louisville · US

Funding

WESTERN REHABILITATION RESEARCH NETWORKR24HD039629 · NICHD · UNIVERSITY OF WASHINGTON · PI ANDERSON, MARJORIE E · 2000 to 2004
$4.8M
LOCOMOTOR THERAPY TRIAL FOR SPINAL CORD INJURYU01HD037439 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOBKIN, BRUCE HARVEY · 1999 to 2003
$3.3M
NICHD NIH HHS R24 HD039629NICHD NIH HHS R24 HD39629NICHD NIH HHS U01 HD037439PHS HHS R01 H37439
6 · The paper itself

Abstract

backgroundThe Spinal Cord Injury Locomotor Trial (SCILT) compared 12 weeks of step training with body weight support on a treadmill (BWSTT) that included overground practice to a defined but more conventional overground mobility intervention (CONT) in patients with incomplete traumatic SCI within 8 weeks of onset. No previous studies have reported walking-related outcomes during rehabilitation.

methodsThis single-blinded, randomized trial entered 107 American Spinal Injury Association (ASIA) C and D patients and 38 ASIA B patients with lesions between C5 and L3 who were unable to walk on admission for rehabilitation. The Functional Independence Measure (FIM-L) for walking, 15-m walking speed, and lower extremity motor score (LEMS) were collected every 2 weeks.

resultsNo significant differences were found at entry and during the treatment phase (12-week mean FIM-L = 5, velocity = 0.8 m/s, LEMS = 35, distance walked in 6 min = 250 m). Combining the 2 arms, a FIM-L >or= 4 was achieved in < 10% of ASIA B patients, 92% of ASIA C patients, and all of ASIA D patients. Walking speed of >or= 0.6 m/s correlated with a LEMS near 40 or higher.

conclusionsFew ASIA B and most ASIA C and D patients achieved functional walking ability by the end of 12 weeks of BWSTT and CONT, consistent with the primary outcome data at 6 months. Walking-related measures assessed at 2-week intervals reveal that time after SCI is an important variable for entering patients into a trial with mobility outcomes. By about 6 weeks after entry, most patients who will recover have improved their FIM-L to >3 and are improving in walking speed. Future trials may reduce the number needed to treat by entering patients with FIM-L < 4 at > 8 weeks after onset if still graded ASIA B and at > 12 weeks if still ASIA C.

Indexed as

AdultDisability EvaluationExercise TherapyHumansRecovery of FunctionSingle-Blind MethodSpinal Cord InjuriesTime FactorsTreatment OutcomeWalking

Identifiers

PMID17172551
PMCPMC4110057
OpenAlexW2103966320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.