ArticleThe Plant cell2006
Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 99 citations in OpenAlex.
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- Resolving floral development dynamics using genome and single-cell temporal transcriptome of Dendrobium devonianum.Plant biotechnology journal · 2025Article
- Photorespiratory Metabolism and Its Regulatory Links to Plant Defence Against Pathogens.International journal of molecular sciences · 2024Review
- Photorespiration: regulation and new insights on the potential role of persulfidation.Journal of experimental botany · 2023Review
- The potential of metabolomics in assessing global compositional changes resulting from the application of CRISPR/Cas9 technologies.Transgenic research · 2023Article
- Reconstructing herbivore diets: a multivariate statistical approach to interpreting amino acid nitrogen isotope values.Oecologia · 2023Article
- A mutation in THREONINE SYNTHASE 1 uncouples proliferation and transition domains of the root apical meristem: experimental evidence and in silico proposed mechanism.Development (Cambridge, England) · 2022Article
- Investigation of Possible Changes Induced by RNA Silencing in Some Leaf Metabolites of Transgenic Sugar Beet Events.Food chemistry. Molecular sciences · 2022Article
- Metabolic Circuits in Sap Extracts Reflect the Effects of a Microbial Biostimulant on Maize Metabolism under Drought Conditions.Plants (Basel, Switzerland) · 2022Article
- Genome-wide association of the metabolic shifts underpinning dark-induced senescence in Arabidopsis.The Plant cell · 2022Article
- Effective Mechanisms for Improving Seed Oil Production in Pennycress (Frontiers in plant science · 2022Article
- The Impact of Photorespiratory Glycolate Oxidase Activity onMetabolites · 2021Article
- Article
- Genotypic Variation of Nitrogen Use Efficiency and Amino Acid Metabolism in Barley.Frontiers in plant science · 2021Article
- Article
- Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.Frontiers in cell and developmental biology · 2021Review
- Non-conventional pathways enable pennycress (Thlaspi arvense L.) embryos to achieve high efficiency of oil biosynthesis.Journal of experimental botany · 2020Article
- Fruit metabolic and transcriptional programs differentiate among Andean tomato (Solanum lycopersicum L.) accessions.Planta · 2019Article
- New insights into the metabolism of aspartate-family amino acids in plant seeds.Plant reproduction · 2018Review
- A sorghum NAC gene is associated with variation in biomass properties and yield potential.Plant direct · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amino acids are not only fundamental protein constituents but also serve as precursors for many essential plant metabolites. Although amino acid biosynthetic pathways in plants have been identified, pathway regulation, catabolism, and downstream metabolite partitioning remain relatively uninvestigated. Conversion of Thr to Gly and acetaldehyde by Thr aldolase (EC 4.1.2.5) was only recently shown to play a role in plant amino acid metabolism. Whereas one Arabidopsis thaliana Thr aldolase (THA1) is expressed primarily in seeds and seedlings, the other (THA2) is expressed in vascular tissue throughout the plant. Metabolite profiling of tha1 mutants identified a >50-fold increase in the seed Thr content, a 50% decrease in seedling Gly content, and few other significant metabolic changes. By contrast, homozygous tha2 mutations cause a lethal albino phenotype. Rescue of tha2 mutants and tha1 tha2 double mutants by overproduction of feedback-insensitive Thr deaminase (OMR1) shows that Gly formation by THA1 and THA2 is not essential in Arabidopsis. Seed-specific expression of feedback-insensitive Thr deaminase in both tha1 and tha2 Thr aldolase mutants greatly increases seed Ile content, suggesting that these two Thr catabolic enzymes compete for a common substrate pool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.