ArticleBiophysical journal2007
Solution pH alters mechanical and electrical properties of phosphatidylcholine membranes: relation between interfacial electrostatics, intramembrane potential, and bending elasticity.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
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- Fluorescent Rhein-Loaded Liposomes for In Vivo Biodistribution Study.Pharmaceutics · 2025Article
- Modulating Nonlinear Acoustic Response of Phospholipid-Coated Microbubbles with pH for Ultrasound Imaging.ACS sensors · 2024Article
- A New Cell Line from the Brain of Red Hybrid Tilapia (Animals : an open access journal from MDPI · 2024Article
- Physical Chemistry of Chloroquine Permeation through the Cell Membrane with Atomistic Detail.Journal of chemical information and modeling · 2023Article
- Biocoordination reactions in copper(II) ions and phosphocholine systems including pyrimidine nucleosides and nucleotides.Scientific reports · 2023Article
- From Grape By-Products to Enriched Yogurt Containing Pomace Extract Loaded in Nanotechnological Nutriosomes Tailored for Promoting Gastro-Intestinal Wellness.Antioxidants (Basel, Switzerland) · 2023Article
- Tuning the Extracellular Vesicles Membrane through Fusion for Biomedical Applications.Journal of functional biomaterials · 2023Article
- Heterosynaptic plasticity in biomembrane memristors controlled by pH.MRS bulletin · 2023Article
- In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin.International journal of molecular sciences · 2021Article
- Sandwich Multi-Material 3D-Printed Polymers: Influence of Aging on the Impact and Flexure Resistances.Polymers · 2021Article
- A Ready-to-Use Metal-Supported Bilayer Lipid Membrane Biosensor for the Detection of Phenol in Water.Membranes · 2021Article
- On the Coupling between Mechanical Properties and Electrostatics in Biological Membranes.Membranes · 2021Review
- Effect of Selected Anionic and Cationic Drugs Affecting the Central Nervous System on Electrical Properties of Phosphatidylcholine Liposomes: Experiment and Theory.International journal of molecular sciences · 2021Article
- Article
- Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches.Molecules (Basel, Switzerland) · 2020Review
- The Modulating Effect of p-Coumaric Acid on The Surface Charge Density of Human Glioblastoma Cell Membranes.International journal of molecular sciences · 2019Article
- Interaction of a Polyarginine Peptide with Membranes of Different Mechanical Properties.Biomolecules · 2019Article
- Competing for the same space: protons and alkali ions at the interface of phospholipid bilayers.Biophysical reviews · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solution pH affects numerous biological processes and some biological membranes are exposed to extreme pH environments. We utilized micropipette aspiration of giant unilamellar vesicles composed of 1-stearoyl-2-oleoyl-phosphatidylcholine to characterize the effect of solution pH (2-9) on membrane mechanical properties. The elastic area compressibility modulus was unaffected between pH 3 and 9 but was reduced by approximately 30% at pH 2. Fluorescence experiments utilizing the phase-sensitive probe Laurdan confirmed gel-phase characteristics at pH 2, explaining the reduction of membrane elasticity. The membrane bending stiffness, kc, increased by approximately 40% at pH 4 and pH 9 over the control value at pH 6.5. Electrophoretic mobility measurements indicate that these changes are qualitatively consistent with theoretical models that predict the effect of membrane surface charge density and Debye length on kc, substantiating a coupling between the mechanical and interfacial electrical properties of the membrane. The effect of pH on intramembrane electrical properties was examined by studying the spectral shifts of the potentiometric probe di-8 ANEPPS. The intramembrane (dipole) potential (Psid) increased linearly as the solution pH decreased in a manner consistent with the partitioning of hydroxide ions into the membrane. However, changes in Psid did not correlate with changes in kc. These mechanical and electrical studies lead to the conclusion that the effect of pH on membrane bending stiffness results from alterations in interfacial, as opposed to intramembrane, electrostatics.
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